Results 91 to 100 of about 10,659 (171)

Dynamic Combinatorial Chemistry Unveils Nsp10 Inhibitors with Antiviral Potential Against SARS‐CoV‐2

Chemistry – A European Journal, Volume 31, Issue 4, January 17, 2025.
This study investigates antiviral strategies targeting SARS‐CoV‐2 by disrupting the protein‐protein interactions of Nsp10 with Nsp14 and Nsp16, which are essential for viral survival. It employs target‐directed dynamic combinatorial chemistry for the identification and synthesis of inhibitors.
Ravindra P. Jumde, Gwenaëlle Jézéquel, Margarida Saramago, Nicolas Frank, Sebastian Adam, Marta V. Cunha, Chantal D. Bader, Antonia P. Gunesch, Natalie M. Köhler, Sandra Johannsen, Spyridon Bousis, Thomas Pietschmann, Rute G. Matos, Rolf Müller, Cecília M. Arraiano, Anna K. H. Hirsch   +15 more
wiley   +1 more source

First Complete Genome Sequence of a Feline Alphacoronavirus 1 Strain from Brazil

Microbiology Resource Announcements, 2019
We identified a strain of Alphacoronavirus 1 , FCoV-SB22, from a pool of fecal samples from domestic cats from a rural settlement in the municipality of Santa Bárbara, Pará, Brazil. The nucleotide identity with feline coronavirus was 91.5%.
Bruno de Cássio Veloso de Barros, Ceyla Maria Oeiras de Castro, Diego Pereira, Laila Graziela Ribeiro, José Wandilson Barboza Duarte Júnior, Samir Mansour Moraes Casseb, Gustavo Moraes Holanda, Ana Cecília Ribeiro Cruz, Edivaldo Costa Sousa Júnior, Joana D’Arc Pereira Mascarenhas   +9 more
openaire   +2 more sources

Structural Immunology of SARS‐CoV‐2

Immunological Reviews, Volume 329, Issue 1, January 2025.
ABSTRACT The SARS‐CoV‐2 spike (S) protein has undergone significant evolution, enhancing both receptor binding and immune evasion. In this review, we summarize ongoing efforts to develop antibodies targeting various epitopes of the S protein, focusing on their neutralization potency, breadth, and escape mechanisms.
Meng Yuan, Ian A. Wilson
wiley   +1 more source

Next‐Generation Vaccines for Co‐Circulating PEDV and TGEV: Integrating Nucleic Acid Platforms, Mucosal Delivery, and AI–Driven Antigen Design

Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.
Porcine epidemic diarrhea virus (PEDV) and transmissible gastroenteritis virus (TGEV) are causative agents of acute enteric diseases in pigs and have a high contagion potential. These coronaviruses (CoVs) impose substantial economic losses on global pork production, particularly affecting lactating piglets where coinfections occur. Although traditional
Xiaojun Hu, Zhenshan Wang, Shen Wang, Hongyu Sun, Na Feng, Entao Li, Xianzhu Xia, Guixue Hu, Feihu Yan, Bin Li   +9 more
wiley   +1 more source

Attenuation and characterization of porcine enteric alphacoronavirus strain GDS04 via serial cell passage

Veterinary Microbiology, 2019
Porcine enteric alphacoronavirus (PEAV) is a newly identified swine enteropathogenic coronavirus that causes watery diarrhea in newborn piglets. In this study, an original, highly virulent PEAV strain GDS04 was serially passaged in Vero cells. The virus titers and sizes of syncytia increased gradually with the cell passages. Newborn piglets were orally
Xu, Zhichao, Lin, Ying, Zou, Chuangchao, Peng, Peng, Wu, Yanan, Wei, Ying, Liu, Yuan, Gong, Lang, Cao, Yongchang, Xue, Chunyi   +9 more
openaire   +2 more sources

Determination of Ferret Enteric Coronavirus Genome in Laboratory Ferrets

Emerging Infectious Diseases, 2017
Ferret enteric coronavirus (FRECV) RNA was detected in laboratory ferrets. Analysis of the complete genome sequence of 2 strains, FRCoV4370 and FRCoV063, revealed that FRECV shared 49.9%–68.9% nucleotide sequence identity with known coronaviruses.
Tian-Cheng Li, Sayaka Yoshizaki, Michiyo Kataoka, Yen Hai Doan, Yasushi Ami, Yuriko Suzaki, Tomofumi Nakamura, Naokazu Takeda, Takaji Wakita   +8 more
doaj   +1 more source

Differential Susceptibility to Porcine Deltacoronavirus: Ducks Show Greater Vulnerability Than Geese

Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.
Porcine deltacoronavirus (PDCoV), an enteropathogenic coronavirus belonging to the Deltacoronavirus genus, is globally distributed and represents a significant viral enteric disease in pigs. It primarily causes severe diarrhea in pigs, especially in newborn piglets, with high fatality rates, resulting in substantial losses to the pig farming industry ...
Renqiang Liu, Shuhuai Meng, Lei Shuai, Hao Zhang, Guangli Hu, Huijuan Guo, Jianfei Chen, Dan Shan, Yakun Du, Yongchang Cao, Zhigao Bu, Zhiyuan Wen, Nan-hua Chen   +12 more
wiley   +1 more source

Distribution and Regulation of RIG‐I in Porcine Intestine During TGEV and PDCoV Infection

Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.
Transmissible gastroenteritis virus (TGEV) and porcine deltacoronavirus (PDCoV) are major enteric coronaviruses responsible for severe diarrhea in neonatal piglets. Retinoic acid‐inducible gene I (RIG‐I) is a key sensor against RNA viruses, yet its distribution in the porcine intestine and regulatory roles during TGEV and PDCoV infections remain ...
Hui Zeng, Xuan Wu, Xinyue Zhang, Yunlei Cao, Rongfeng Tang, Yuchen Li, Qian Yang, Nan-hua Chen   +7 more
wiley   +1 more source

Detection of alpha- and betacoronaviruses in rodents from Yunnan, China

Virology Journal, 2017
Background Rodents represent the most diverse mammals on the planet and are important reservoirs of human pathogens. Coronaviruses infect various animals, but to date, relatively few coronaviruses have been identified in rodents worldwide.
Xing-Yi Ge, Wei-Hong Yang, Ji-Hua Zhou, Bei Li, Wei Zhang, Zheng-Li Shi, Yun-Zhi Zhang   +6 more
doaj   +1 more source

In situ structure and dynamics of an alphacoronavirus spike protein by cryo-ET and cryo-EM [PDF]

, 2022
Cheng-Yu Huang, Piotr Drączkowski, Yong‐Sheng Wang, Chia‐Yu Chang, Yu-Chun Chien, Yun‐Han Cheng, Yimin A. Wu, Chun-Hsiung Wang, Yuan‐Chih Chang, Yen‐Chen Chang, Tzu‐Jing Yang, Yu-Xi Tsai, Kay‐Hooi Khoo, Hui‐Wen Chang, Shang‐Te Danny Hsu   +14 more
openalex   +1 more source