Results 101 to 110 of about 11,673 (180)

Prevention of Porcine Epidemic Diarrhea Virus With Nanotube‐Adjuvanted Oral DNA Vaccines

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Porcine epidemic diarrhea virus (PEDV) causes severe diarrhea in piglets. The ideal route of protection against PEDV for piglets is through passive (lactogenic) immunity, which is not provided by current inactivated and subunit vaccines on the market. In this study, we investigated whether a DNA vaccine encoding the full PEDV spike protein adjuvanted ...
Hsing-Chieh Wu, Thu-Dung Doan, Wan-Chen Chang, Min-Kung Hsu, Hsian-Yu Wang, Jiahorng Liaw, Chia-Jung Chang, Chun-Yen Chu, Nan-Hua Chen   +8 more
wiley   +1 more source

Detection of alpha- and betacoronaviruses in rodents from Yunnan, China

Virology Journal, 2017
Background Rodents represent the most diverse mammals on the planet and are important reservoirs of human pathogens. Coronaviruses infect various animals, but to date, relatively few coronaviruses have been identified in rodents worldwide.
Xing-Yi Ge, Wei-Hong Yang, Ji-Hua Zhou, Bei Li, Wei Zhang, Zheng-Li Shi, Yun-Zhi Zhang   +6 more
doaj   +1 more source

Recent transmission of a novel alphacoronavirus, bat coronavirus HKU10, from Leschenault's rousettes to Pomona leaf-nosed bats: first evidence of interspecies transmission of coronavirus between bats of different suborders.

, 2012
Although coronaviruses are known to infect various animals by adapting to new hosts, interspecies transmission events are still poorly understood. During a surveillance study from 2005 to 2010, a novel alphacoronavirus, BatCoV HKU10, was detected in two ...
Lau, Susanna K. P., Woo, Patrick C. Y., Li, Kenneth S. M., Poon, Rosana W. S., Fan, Rachel Y. Y., Zheng, Bo-Jian, Yuen, Kwok-Yung, Wang, Ming, Shek, Chung-Tong, Lam, Carol S. F., Guo, Rongtong, Chan, Kwok-Hung, Tsang, Alan K. L., Lau, Susanna K.P., Choi, Garnet K. Y., L. Tsang, Alan K., Wang, Sylvia Y. H., Li, Kenneth S.M., Wong, Beatrice H. L., Woo, PCY, Lam, SF, Wong, BHL, Guo, R, Wang, M, Shek, CT, Fan, YY, Chan, KH, Wang, SYH, Poon, RWS, Li, KSM, Zheng, B, Yuen, KY, Lau, SKP, Tsang, KL, Choi, KY   +34 more
core   +1 more source

A genus-specific nsp12 region impacts polymerase assembly in Alphacoronavirus and Gammacoronavirus

Journal of Biological Chemistry
Coronavirus relevancy for human health has surged over the past 20 years as they have a propensity for spillover into humans from animal reservoirs resulting in pandemics such as COVID-19. The diversity within the Coronavirinae subfamily and high infection frequency in animal species worldwide creates a looming threat that calls for research across all
Peter J. Hoferle, Thomas K. Anderson, Robert N. Kirchdoerfer   +2 more
openaire   +2 more sources

SARS-CoV related Betacoronavirus and diverse Alphacoronavirus members found in western old-world

Virology, 2018
(Uploaded by Plazi for the Bat Literature Project) The emergence of SARS-CoV and MERS-CoV, triggered the discovery of a high diversity of coronaviruses in bats. Studies from Europe have shown that coronaviruses circulate in bats in France but this reflects only a fraction of the whole diversity.
Ar Gouilh, Meriadeg, Puechmaille, Sébastien, Diancourt, Laure, Vandenbogaert, Mathias, Serra-Cobo, Jordi, Lopez Roïg, Marc, Brown, Paul, Moutou, François, Caro, Valerie, Vabret, Astrid, Manuguerra, Jean-Claude   +10 more
openaire   +6 more sources

Structure of the RBD of TGEV and conformation of the receptor-binding edge in Alphacoronavirus.

, 2012
A. Ribbon diagram of RBD protein structure with β-strands in light or dark blue, coils in orange, and helix in red. A β-bulge at β-strand 5 is shown in magenta.
César Santiago (146919), Juan Reguera (146914), Desiderio Ordoño (146932), Gaurav Mudgal (146926), Luis Enjuanes (146937), José M. Casasnovas (146944)   +5 more
core   +1 more source

Detection of avian, murine, bovine, shrew, and bat coronaviruses in wild mammals from Mexico

Virology Journal
Coronaviruses infect a wide range of animal and human hosts. Some human coronaviruses, such as SARS-CoV, MERS-CoV, and SARS-CoV-2, originated in animals, with bats often serving as ancestral hosts.
Jocelyn Medina-Gudiño, Yolanda López-Vidal, J. Adolfo Pardo-Tovar, Lauro Velázquez-Salinas, Francisco Javier Basurto-Alcántara   +4 more
doaj   +1 more source

Structure of Alphacoronavirus Transmissible Gastroenteritis Virus nsp1 Has Implications for Coronavirus nsp1 Function and Evolution

, 2013
Coronavirus nsp1 has been shown to induce suppression of host gene expression and to interfere with the host immune re- sponse. However, the mechanism is currently unknown.
Jansson, Anna M.,
core   +1 more source

Detection and characterization of diverse alpha- and betacoronaviruses from bats in China

, 2016
Bats have been implicated as important reservoir hosts of alpha- and betacoronaviruses. In this study, diverse coronaviruses (CoVs) were detected in 50 of 951 (positive rate 5.3\%) intestinal specimens of eight bat species collected in four provinces and
Yang, Weihong, Lu, Guanjun, Tu, Changchun, Xu, Lin, He, Biao, Li, Xingyu, Jiang, Tinglei, Zhang, Yuzhen, Zhang, Fuqiang, Hu, Tingsong, Chen, Gang, Fan, Quanshui, Feng, Jiang, Zhang, Hailin, Feng, Yun   +14 more
core   +1 more source

Identification of a new alphacoronavirus (Coronaviridae: Alphacoronavirus) associated with the greater horseshoe bat (Rhinolophus ferrumequinum) in the south of European part of Russia.

Voprosy virusologii
Bats are recognized as primary natural reservoirs for alpha- and betacoronaviruses. The interspecies transmission of bat coronaviruses to other mammalian hosts, including livestock and humans, can lead to epidemics, epizootics, and global pandemics.This study aims to describe coronaviruses associated with horseshoe bats (Rhinolophus spp.) in the ...
Sergey V. Lenshin, Tatyana V. Vishnevskaya, Alexey V. Romashin, Yulia I. Bulycheva, Oleg I. Vyshemirsky, Sophya A. Solovyeva, Asya K. Gitelman, Alexey S. Pazilin, Dmitry K. Lvov, Ben Hu, Zheng-Li Shi, Sergey V. Alkhovsky   +11 more
openaire   +2 more sources