Results 31 to 40 of about 917 (132)
Cardiac pathology and molecular epidemiology by avian leukosis viruses in Japan. [PDF]
PLoS ONE, 2014 Epidemiological studies suggest that retroviruses, including human immunodeficiency virus type 1, are associated with cardiomyopathy and myocarditis, but a causal relationship remains to be established.
Sayuri Nakamura +7 more
doaj +2 more sources
Identification of Cables1 as a critical host factor that promotes ALV-J replication via genome-wide CRISPR/Cas9 gene knockout screening. [PDF]
J Biol ChemAvian leukosis virus subgroup J (ALV-J), a member of the genus Alpharetrovirus, possesses a small genome and exploits a vast array of host factors during its replication cycle. To identify host factors required for ALV-J replication and potentially guide
Liu P +16 more
europepmc +2 more sources
Viruses, 2016 Infectious retrovirus particles contain two copies of unspliced viral RNA that serve as the viral genome. Unspliced retroviral RNA is transcribed in the nucleus by the host RNA polymerase II and has three potential fates: (1) it can be spliced into ...
Rebecca J. Kaddis Maldonado +1 more
doaj +2 more sources
Functional and structural characterization of the integrase from the prototype foamy virus
Nucleic Acids Research, 2008 Establishment of the stable provirus is an essential step in retroviral replication, orchestrated by integrase (IN), a virus-derived enzyme. Until now, available structural information was limited to the INs of human immunodeficiency virus type 1 (HIV-1),
E. Valkov +6 more
semanticscholar +2 more sources
Protease-mediated maturation of M-PMV reverse transcriptase into a functional heterodimer. [PDF]
Protein SciAbstract Reverse transcriptase (RT) of retroviruses orchestrates viral replication, yet its structural diversity remains poorly understood. Well‐studied RTs, such as those from HIV‐1, murine leukemia virus, and avian myeloblastosis virus, were characterized decades ago, but less prominent retroviruses have escaped detailed analysis.
Kapisheva M +6 more
europepmc +2 more sources
Differential Sensitivities of Retroviruses to Integrase Strand Transfer Inhibitors
Journal of Virology, 2011 Integrase inhibitors are emerging anti-human immunodeficiency virus (HIV) drugs, and multiple retroviruses and transposable elements were evaluated here for susceptibilities to raltegravir (RAL) and elvitegravir (EVG).
Y. Koh, Kenneth A. Matreyek, A. Engelman
semanticscholar +2 more sources
mLife, Volume 2, Issue 2, Page 201-208, June 2023., 2023 Abstract Mammalian endogenous retroviruses (ERVs) are ancient retroviruses that have been integrated into genomes. ERVs were believed to be inactive until the discovery of ERV transcription in the mouse genome. However, the transcription level and function of ERV elements in mammalian genomes are not well understood.
Zheng Li +5 more
wiley +1 more source
CAR‐NK cells: the next wave of cellular therapy for cancer
Clinical &Translational Immunology, Volume 10, Issue 4, 2021., 2021 NK cells can be derived from various sources (PB, UCB, HSC, iPSC, NK cell lines) and can be engineered to express a chimeric antigen receptor (CAR) to target various surface antigens on cancer cells. These CAR‐NK cells can be used as off‐the‐shelf adoptive cellular therapy to treat patients with various malignancies.
May Daher +3 more
wiley +1 more source
Supplementary data for the manuscript "An ancient alpharetrovirus lineage in bats: evolutionary insights and possible roles in ...
Aris Katzourakis, Emma Fay Harding
core +6 more sources
Gene Therapy for Primary Immunodeficiency
HemaSphere, Volume 5, Issue 1, January 2021., 2021 Over the past 3 decades, there has been significant progress in refining gene therapy technologies and procedures. Transduction of hematopoietic stem cells ex vivo using lentiviral vectors can now create a highly effective therapeutic product, capable of reconstituting many different immune system dysfunctions when reinfused into patients.
Benjamin C. Houghton, Claire Booth
wiley +1 more source