Inhibition of Alpharetrovirus Replication by a Range of Human APOBEC3 Proteins [PDF]
Journal of Virology, 2007 ABSTRACT The mammalian APOBEC3 family of cytidine deaminases includes members that can act as potent inhibitors of retroviral infectivity and retrotransposon mobility. Here, we have examined whether the alpharetrovirus Rous sarcoma virus (RSV) is susceptible to inhibition by a range of human APOBEC3 proteins.
Bryan Cullen, Heather L Wiegand
exaly +4 more sources
A novel recombinant ALV-K carrying ALV-J-derived LTR, pol, and 3’UTR from Chinese indigenous chicken breeds exhibits enhanced replication and increased hemangioma-associated pathogenicity [PDF]
BMC Veterinary ResearchAvian leukosis virus (ALV) is a prototypical alpharetrovirus that can induce various tumors and cause serious immunosuppression, posing severe threats to the poultry industry.
Jinqun Li +8 more
doaj +3 more sources
Genome-wide characterization and comparison of endogenous retroviruses among 3 duck reference genomes [PDF]
Poultry Science: Endogenous retroviruses (ERV) are viral genomes integrated into the host genome and can be stably inherited. Although ERV sequences have been reported in some avian species’ genome, the duck endogenous retroviruses (DERV) genome has yet to be ...
Yuan Bai +14 more
doaj +3 more sources
Current knowledge on the epidemiology and prevention of Avian leukosis virus in China [PDF]
Poultry Science: Avian leukosis virus (ALV) is an enveloped retrovirus with a single-stranded RNA genome, belonging to the genus Alpharetrovirus within the family Retroviridae.
Lei Tan +9 more
doaj +3 more sources
Biochemical characterization of novel retroviral integrase proteins. [PDF]
PLoS ONE, 2013 Integrase is an essential retroviral enzyme, catalyzing the stable integration of reverse transcribed DNA into cellular DNA. Several aspects of the integration mechanism, including the length of host DNA sequence duplication flanking the integrated ...
Allison Ballandras-Colas +4 more
doaj +4 more sources
Interplay between the alpharetroviral Gag protein and SR Proteins SF2 and SC35 in the nucleus [PDF]
Frontiers in Microbiology, 2015 Retroviruses are positive-sense, single-stranded RNA viruses that reverse transcribe their RNA genomes into double-stranded DNA for integration into the host cell chromosome.
Breanna L. Rice +4 more
doaj +3 more sources
Frontiers in Veterinary Science, 2022 Avian leukosis caused by avian leukosis virus (ALV), belonging to the genus Alpharetrovirus of the family Retroviridae, is associated with benign and malignant tumors in hemopoietic cells in poultry.
Guanggang Qu +11 more
doaj +2 more sources
Detection of lymphoproliferative disease virus in domestic and wild turkeys through RNAscope in situ hybridization and immunohistochemistry. [PDF]
J Vet Diagn InvestDiagnosis of lymphoid hyperplasia and neoplasia due to lymphoproliferative disease virus (LPDV; Retroviridae, Alpharetrovirus) infection in turkeys is challenging due to histopathologic similarities with nonspecific inflammation and cellular responses to
Goodwin CC +6 more
europepmc +2 more sources
PLoS GeneticsAlpharetroviruses are an important group of pathogens that are known for causing leukemias and tumors and were historically considered to be restricted to avian hosts.
Emma F. Harding +4 more
semanticscholar +2 more sources
Diversity and evolutionary history of endogenous retroviruses in the genome of Manis pentadactyla [PDF]
Microbiology SpectrumEndogenous retroviruses (ERVs), remnants of ancient viral infections integrated into host genomes, serve as invaluable molecular fossils for studying viral evolution.
Tiancheng Zhang +4 more
doaj +2 more sources