Improved alpharetrovirus-based Gag.MS2 particles for efficient and transient delivery of CRISPR-Cas9 into target cells [PDF]
Molecular Therapy - Nucleic Acids, 2022 DNA-modifying technologies, such as the CRISPR-Cas9 system, are promising tools in the field of gene and cell therapies. However, high and prolonged expression of DNA-modifying enzymes may cause cytotoxic and genotoxic side effects and is therefore ...
Philippe Danzer Barbosa +2 more
exaly +5 more sources
Unique Structure and Distinctive Properties of the Ancient and Ubiquitous Gamma-Type Envelope Glycoprotein [PDF]
Viruses, 2023 After the onset of the AIDS pandemic, HIV-1 (genus Lentivirus) became the predominant model for studying retrovirus Env glycoproteins and their role in entry.
Welkin Johnson
exaly +4 more sources
Comparison of Endogenous Alpharetroviruses (ALV-like) across Galliform Species: New Distant Proviruses [PDF]
Microorganisms, 2023 The Genus Alpharetrovirus contains viruses pathogenic mainly for chickens, forming the Avian Sarcoma and Leukosis Virus group (ASLV). Cells of most Galliform species, besides chickens, contain genetic elements (endogenous retroviruses, ERVs) that could ...
Sergio Fandiño +3 more
doaj +2 more sources
A Structural Perspective of the Role of IP6 in Immature and Mature Retroviral Assembly [PDF]
Viruses, 2021 The small cellular molecule inositol hexakisphosphate (IP6) has been known for ~20 years to promote the in vitro assembly of HIV-1 into immature virus-like particles.
Martin Obr +2 more
doaj +2 more sources
Acetylation-mediated regulation of ALV viral proteins: Implications for retroviral inhibition. [PDF]
PLoS PathogensAvian leukosis virus (ALV), a prototypic alpharetrovirus, serves as a pivotal model for studying retroviral biology due to its well-characterized replication cycle, genetic tractability, and evolutionary conservation with clinically relevant retroviruses
Ning Cui +6 more
doaj +2 more sources
Transcriptome mining reveals diversity and evolution of circulating and endogenous amphibian retroviruses [PDF]
RetrovirologyBackground The evolutionary history of retroviruses and their impact on vertebrate evolution remains poorly understood, particularly in non-mammalian hosts.
Emma F. Harding +4 more
doaj +2 more sources
Inhibition of Alpharetrovirus Replication by a Range of Human APOBEC3 Proteins [PDF]
Journal of Virology, 2007 ABSTRACT The mammalian APOBEC3 family of cytidine deaminases includes members that can act as potent inhibitors of retroviral infectivity and retrotransposon mobility. Here, we have examined whether the alpharetrovirus Rous sarcoma virus (RSV) is susceptible to inhibition by a range of human APOBEC3 proteins.
Bryan Cullen, Heather L Wiegand
exaly +3 more sources
Diversity and evolutionary history of endogenous retroviruses in the genome of Manis pentadactyla [PDF]
Microbiology SpectrumEndogenous retroviruses (ERVs), remnants of ancient viral infections integrated into host genomes, serve as invaluable molecular fossils for studying viral evolution.
Tiancheng Zhang +4 more
doaj +2 more sources
Importin-β Family Members Mediate Alpharetrovirus Gag Nuclear Entry via Interactions with Matrix and Nucleocapsid [PDF]
Journal of Virology, 2006 ABSTRACT The retroviral Gag polyprotein orchestrates the assembly and release of virus particles from infected cells. We previously reported that nuclear transport of the Rous sarcoma virus (RSV) Gag protein is intrinsic to the virus assembly pathway.
Leslie Parent, Lisa Scheifele
exaly +3 more sources
Single Amino Acid Residue W33 of tva Receptor Is Critical for Viral Entry and High-Affinity Binding of Avian Leukosis Virus Subgroup K [PDF]
VirusesAvian leukosis virus (ALV), the prototypical alpharetrovirus, causes tumorigenesis, immunosuppression, and wasting disease in poultry. The ALV genus is classified into ten subgroups, which differ in their host range, cell tropism, and receptor usage. The
Eliška Gáliková +5 more
doaj +2 more sources