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Alphavirus Hybrid Virion Vaccines

1996
Many members of the alphavirus family are important human or veterinary pathogens. These viruses are extremely similar in molecular architecture yet differ in host range and in the pathological consequences of infection. Despite marked structural conservation, the various species are inefficient in eliciting immunological cross protection. Previously(l)
A, Shafferman   +10 more
openaire   +2 more sources

Alphavirus-Based Antigen Preparation

2020
Alphavirus-based vectors present an efficient approach for antigen preparation applied for vaccine development. Semliki Forest virus, Sindbis virus, and Venezuelan equine encephalitis virus have been engineered for high-level expression of antigens targeting infectious diseases and tumors.
openaire   +2 more sources

Alphavirus-Based Expression Systems

1996
Alphaviruses are enveloped positive-strand RNA viruses transmitted to vertebrate hosts via mosquito vectors (reviewed in 34). In the last several years, the alphavirus RNA replication and packaging machinery have been exploited for cytoplasmic expression of heterologous RNAs and proteins in animal cells (for reviews see 3, 24, 27).
openaire   +2 more sources

Alphavirus Entry into Host Cells

2015
Viruses have evolved to exploit the vast complexity of cellular processes for their success within the host cell. The entry mechanisms of enveloped viruses (viruses with a surrounding outer lipid bilayer membrane) are usually classified as being either endocytotic or fusogenic.
Ricardo, Vancini   +2 more
openaire   +2 more sources

Purification and Concentration of Alphavirus

Cold Spring Harbor Protocols, 2012
The alphaviruses Semliki Forest virus and Sindbis virus have been used frequently as expression vectors in vitro and in vivo. Usually, these systems consist of replication-deficient vectors that require a helper vector for packaging of recombinant particles. Replication-proficient vectors have also been engineered.
openaire   +2 more sources

A molecular understanding of alphavirus entry and antibody protection

Nature Reviews Microbiology, 2022
Arthur S Kim, Michael Diamond
exaly  

Therapeutic alphavirus cross-reactive E1 human antibodies inhibit viral egress

Cell, 2021
Lauren E Williamson   +2 more
exaly  

Pan-protective anti-alphavirus human antibodies target a conserved E1 protein epitope

Cell, 2021
Arthur S Kim   +2 more
exaly  

Distinct Cellular Tropism and Immune Responses to Alphavirus Infection

Annual Review of Immunology, 2022
Julie M Fox, Michael S Diamond
exaly  

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