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Alphavirus Hybrid Virion Vaccines
1996Many members of the alphavirus family are important human or veterinary pathogens. These viruses are extremely similar in molecular architecture yet differ in host range and in the pathological consequences of infection. Despite marked structural conservation, the various species are inefficient in eliciting immunological cross protection. Previously(l)
A, Shafferman +10 more
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Alphavirus-Based Antigen Preparation
2020Alphavirus-based vectors present an efficient approach for antigen preparation applied for vaccine development. Semliki Forest virus, Sindbis virus, and Venezuelan equine encephalitis virus have been engineered for high-level expression of antigens targeting infectious diseases and tumors.
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Alphavirus-Based Expression Systems
1996Alphaviruses are enveloped positive-strand RNA viruses transmitted to vertebrate hosts via mosquito vectors (reviewed in 34). In the last several years, the alphavirus RNA replication and packaging machinery have been exploited for cytoplasmic expression of heterologous RNAs and proteins in animal cells (for reviews see 3, 24, 27).
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Alphavirus Entry into Host Cells
2015Viruses have evolved to exploit the vast complexity of cellular processes for their success within the host cell. The entry mechanisms of enveloped viruses (viruses with a surrounding outer lipid bilayer membrane) are usually classified as being either endocytotic or fusogenic.
Ricardo, Vancini +2 more
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Purification and Concentration of Alphavirus
Cold Spring Harbor Protocols, 2012The alphaviruses Semliki Forest virus and Sindbis virus have been used frequently as expression vectors in vitro and in vivo. Usually, these systems consist of replication-deficient vectors that require a helper vector for packaging of recombinant particles. Replication-proficient vectors have also been engineered.
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A molecular understanding of alphavirus entry and antibody protection
Nature Reviews Microbiology, 2022Arthur S Kim, Michael Diamond
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Therapeutic alphavirus cross-reactive E1 human antibodies inhibit viral egress
Cell, 2021Lauren E Williamson +2 more
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Pan-protective anti-alphavirus human antibodies target a conserved E1 protein epitope
Cell, 2021Arthur S Kim +2 more
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Distinct Cellular Tropism and Immune Responses to Alphavirus Infection
Annual Review of Immunology, 2022Julie M Fox, Michael S Diamond
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