Results 81 to 90 of about 2,723,375 (158)
, 2020 Hypophosphatasia (HPP) is a rare genetic disease with diverse symptoms and a heterogeneous severity of onset with underlying mutations in the ALPL gene encoding the ectoenzyme Tissue-nonspecific alkaline phosphatase (TNAP).
Borst, Angela +6 more
core +1 more source
, 2023 In response to force application, biological reactions occur in the periodontal ligament that causes the orthodontic tooth movement. Differential expression of genes such as ALPL, FGF7, PDRM1, and NR4A2 are involved in the exposure to tension or ...
Mora Rodríguez, Rodrigo Antonio +1 more
core +1 more source
Novel Alpl Genetic Alteration Associated With An Odontohypophosphatasia Phenotype.
, 2015 Hypophosphatasia (HPP) is an inherited disorder of mineral metabolism caused by mutations in ALPL, encoding tissue non-specific alkaline phosphatase (TNAP).
Foster, Brian L +9 more
core +2 more sources
The Anatomical Record, Volume 309, Issue 11, Page 3375-3396, November 2026.Abstract The vertebrate skull is composed of bones derived from neural crest cells and mesoderm. The evolutionary capacity of the skull has been linked, in part, to the emergence of neural crest cells; however, this increased capacity for evolutionary change requires that variation within neural crest‐ and mesoderm‐derived bones remains partly ...
Alyssa C. Moore +5 more
wiley +1 more source
CTC low-passage cultures express ALPL and have common prostate cancer genetic alterations.
, 2019 A. Low passage CTC cultures display epithelial-like cobblestone morphology. B. A PCR-based assay for human and mouse DNA confirmed the presence of human DNA in the cultures. Human and mouse-specific positive and negative control DNAs (hDNA and msDNA) are
Colin Rothwell (6743741) +20 more
core +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3902-3913, November 2026.Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub +3 more
wiley +1 more source
Background Hypophosphatasia (HPP) is a rare disease caused by deficient activity of tissue-nonspecific alkaline phosphatase (ALP), encoded by the ALPL gene.
Reder, Felix +4 more
core +1 more source
Proteomic signatures of equine dental tooth tissues in ageing and disease
Equine Veterinary Journal, Volume 58, Issue 6, Page 1552-1569, November 2026.Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen +8 more
wiley +1 more source
Journal of Biomedical Materials Research Part A, Volume 114, Issue 11, November 2026.ABSTRACT Hydrocalumite‐like phases, belonging to the layered double hydroxide family, are potential biomaterials for bone repair; however, their cellular effects remain incompletely understood. Here, we evaluated a hydrocalumite‐like material of composition [Ca2Al(OH)₆]Cl·nH2O (abbreviated Ca2Al–Cl) in preosteoblastic MC3T3‐E1 cells, assessing ...
C. J. da Costa Fernandes +4 more
wiley +1 more source
Matrix Vesicle‐Associated SMS2 as a Novel Mediator of Biomineralization
Journal of Extracellular Biology, Volume 5, Issue 11, November 2026.ABSTRACT SGMS2, a gene encoding plasma membrane‐resident sphingomyelin synthase 2, SMS2, has emerged as an important determinant of skeletal ossification. Heterozygous SGMS2 variants are associated with a broad spectrum of bone phenotypes, ranging from rickets‐like deformities in childhood to early‐onset osteoporosis, implicating SMS2 in mineralization
Phillip T. Newton +4 more
wiley +1 more source