Results 61 to 70 of about 10,834 (202)

ALPL regulates pro-angiogenic capacity of mesenchymal stem cells through ATP-P2X7 axis controlled exosomes secretion

Journal of Nanobiotechnology
Background Early-onset bone dysplasia is a common manifestation of hypophosphatasia (HPP), an autosomal inherited disease caused by ALPL mutation. ALPL ablation induces prototypical premature bone ageing characteristics, resulting in impaired osteogenic ...
Jiayi Dong, Wanmin Zhao, Jiangdong Zhao, Ji Chen, Ping Liu, Xueni Zheng, Dehua Li, Yang Xue, Hongzhi Zhou   +8 more
doaj   +1 more source

Analysis of alkaline phosphatase, soluble acid phosphatase, low density lipoprotein and vitamin D binding protein gene polymorphisms as possible gene-candidates participating in mineral bone density determination in women with primary osteoporosis in postmenopause

Научно-практическая ревматология, 2004
Objective. To investigate the distribution of alkaline phosphatase (ALPL), acid phosphatase I (ACPI), receptor lipoprotein low density (LDLR) and vitamin D binding protein (GC) genotypes in osteoporotic ana nonosteoporotic postmenopausal women and the ...
M Y Krylov, V A Myakotkin, L L Benevolenskaya   +2 more
doaj   +1 more source

Hypophosphatasia [PDF]

, 2007
Hypophosphatasia is a rare inherited disorder characterized by defective bone and teeth mineralization, and deficiency of serum and bone alkaline phosphatase activity. The prevalence of severe forms of the disease has been estimated at 1/100 000.
Etienne Mornet, D Fraser, MP Whyte, M Shohat, RM Pauli, CA Moore, D Wenkert, MP Whyte, D Cole, MD Fallon, K Kozlowski, HJ Girschick, HJ Girschick, MP Whyte, MP Whyte, J Beumer 3rd, R Jemmerson, L Hessle, MF Hoylaerts, E Mornet, CR Greenberg, MJRK Weiss, E Mornet, E Mornet, N Sugimoto, M Fukushi, H Shibata, L Zurutuza, G Cai, M Fukushi-Irie, A Taillandier, H Watanabe, M Ito, Y Ishida, H Watanabe, K Komaru, KN Fedde, S Di Mauro, H Orimo, M Nasu, I Brun-Heath, EE Kim, MH Le Du, MP Whyte, JR Eastman, FHS Eberic, PS Henthorn, HL Muller, JC Hu, AS Lia-Baldini, M Herasse, M Robinow, X Lepe, J Millan, H Rasmussen, H Orimo, H Orimo, E Mornet, M Goseki-Sone, S Mumm, H Watanabe, H Watanabe, MP Whyte, CR Greenberg, A Taillandier, M Spentchian, I Brun-Heath, M Spentchian, A Watanabe, PS Henthorn, H Orimo, E Mornet, SJ Iqbal, D Wenkert, HJ Girschick, MP Whyte, RA Cahill, MJ Weiss, SE Antonarakis   +78 more
core   +2 more sources

A Modular Bioinstructive Platform Reveals Mechanistic Insights into Additive‐Free, Topography‐Driven Osteogenesis

Advanced Healthcare Materials, EarlyView.
Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum, Leo A. H. Zeef, Lee A. Stevens, Marco A. N. Domingos, Susan J. Kimber, Mahetab H. Amer   +5 more
wiley   +1 more source

Establishment of human periodontal ligament cell lines with ALPL mutations to mimic dental aspects of hypophosphatasia

Frontiers in Cell and Developmental Biology
IntroductionBesides skeletal symptoms, dental abnormalities are a typical feature of the rare inherited disorder hypophosphatasia (HPP), which is caused by loss of function mutations in the ALPL gene (alkaline phosphatase, biomineralization associated ...
Jana Schiffmaier, Jana Schiffmaier, Sofia Rehling, Sofia Rehling, Katharina Marnet, Katharina Marnet, Angela Borst, Drenka Trivanović, Drenka Trivanović, Drenka Trivanović, Denitsa Docheva, Franz Jakob, Stephanie Graser, Marietta Herrmann, Daniel Liedtke   +14 more
doaj   +1 more source

Packed for Ossification: High‐Density Bioprinting of hPDC Spheroids in HAMA Toward Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez, Maria Paula Marks, Paula Casademunt, Adrián Seijas‐Gamardo, Ioannis Papantoniou, Lorenzo Moroni, Carlos Mota   +6 more
wiley   +1 more source

A Case of the Perinatal Form Hypophosphatasia Caused by a Novel Large Duplication of the ALPL Gene and Report of One Year Follow-up with Enzyme Replacement Therapy

JCRPE, 2019
Hypophosphatasia (HPP) is a rare disease caused by mutations in the ALPL gene encoding tissue-non-specific isoenzyme of alkaline phosphatase (TNSALP). Duplications of the ALPL gene account for fewer than 1% of the mutations causing HPP. It has been shown
Bülent Hacıhamdioğlu, Gamze Özgürhan, Catarina Pereira, Emre Tepeli, Gülşen Acar, Serdar Cömert   +5 more
doaj   +1 more source

Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial [PDF]

, 2014
Background: B vitamins play an important role in homocysteine metabolism, with vitamin deficiencies resulting in increased levels of homocysteine and increased risk for stroke.
Al-Tahan, Aminoff, Aminoff, Donato, Fyfe, Grarup, Grasbeck, Hazra, Hazra, Hsu, Imerslund, Kamatani, Kirsch, Koury, Krintel, Kristiansen, Laurie, Lee, Li, Lin, Manichaikul, Matchar, McDowell, Nguyen, Ntaios, Owczarek-Lipska, Pennypacker, Pruim, Rajan, Reynolds, Selhub, Spence, Spinneker, Stabler, Stone, Stover, Tanaka, Tanner, Toole, Toole, Toprak, Van Den Bossche, Vardy, Wald, Wang, Wang, Webb, Yetley   +47 more
core   +2 more sources

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

A protective role for FGF-23 in local defence against disrupted arterial wall integrity? [PDF]

, 2013
Increasing interest is focusing on the role of the FGF-23/Klotho axis in mediating vascular calcification. However, the underpinning mechanisms have yet to be fully elucidated. Murine VSMCs were cultured in calcifying medium for a 21d period. FGF-23 mRNA
Ben-Dov, Colin Farquharson, Demer, Ding, Dongxing Zhu, El-Abbadi, Eswarakumar, Franceschi, Hu, Isakova, Johnson, Jose Luis Millan, Khatiwala, Kok, Kurosu, Lim, Liu, Liu, Lorenz-Depiereux, Mackenzie, Mackenzie, Mackenzie, Mackenzie, MacRae, MacRae, MacRae, MacRae, MacRae, Medici, Murshed, Nasrallah, Neil C.W. Mackenzie, Rakugi, Razzaque, Roy, Rutsch, Rutsch, Saito, Salasznyk, Sali, Shalhoub, Shimada, Shimada, Shroff, Simmons, Sitara, Sitara, Speer, Speer, Srivaths, Urakawa, Vicky E. MacRae, Voigt, Wolf, Yamamoto, Yilmaz, Zhu, Zhu   +57 more
core   +1 more source