Results 61 to 70 of about 2,723,375 (158)

Integrated Transcriptomics of Human and Canine Osteosarcoma Reveals Species Stemness and Trabectedin Sensitivity

Cancer Science, EarlyView.
Comprehensive comparative molecular framework for human and canine osteosarcomas. Integrated transcriptomic analyses establish a comprehensive comparative molecular framework for human and canine osteosarcomas. By defining species‐specific stemness architectures and drug response dynamics, our findings highlight the necessity of accounting for distinct
Kenta Kono, Yomogi Shiota, Ting‐Ting Shu, Hayato Shibahara, Daiki Kato, Takayuki Nakagawa, Seiji Ohtori, Tadashi Kondo   +7 more
wiley   +1 more source

Chromatin Remodeller BRD9 Orchestrates Odontoblastic Differentiation via Coordinating RUNX2‐KLF4

Cell Proliferation, EarlyView.
During odontoblast lineage commitment, the chromatin remodeller BRD9 acts as a critical epigenetic coordinator, orchestrating the chromatin landscape to facilitate synergistic binding of key transcription factors RUNX2 and KLF4 to target loci for odontogenesis.
Wenrui Zeng, Yuxiu Lin, Yongyan Gao, Delan Huang, Yuanyuan Li, Honglei Ruan, Guohua Yuan, Huan Liu, Zhi Chen   +8 more
wiley   +1 more source

Potential alimentärer Beeinflussbarkeit der Aktivität der Alkalischen Phosphatase bei Hypophosphatasie-assoziierten Mutationen im ALPL-Gen [PDF]

, 2023
Einleitung: Patienten mit Hypophosphatasie, einer genetischen Erkrankung mit funktionsmindernder Mutation im ALPL-Gen, stehen nur begrenzte therapeutische Optionen zur Verfügung.
Wiedemann, Philip
core  

Hypophosphatasia and its role in bone pathology in adults

Лечащий Врач, 2021
Pathogenesis and symptoms of hypophosphatasia were reviewed, in particular in adults, as well as methods of diagnostics and treatment.
K. E. Zotkina, O. M. Lesnyak
doaj  

AFF4 Loss Compromises Osteogenesis of Orofacial Mesenchymal Stem Cells During Alveolar Bone Repair via AMPK‐Mediated Mitophagy

Cell Proliferation, EarlyView.
Compromised alveolar socket healing following tooth extraction upon Aff4 knockout is caused by suppressed osteogenic capacity of orofacial mesenchymal stem cells, which results from defective AMPK‐mediated mitophagy. ABSTRACT Repair of maxillofacial bone defects presents significant clinical challenges.
Li Zhu, Shuo Chen, Guowen Luo, Tingyue Zhang, Hengyi Lin, Yiling Chen, Chenchen Zhou, Shujuan Zou   +7 more
wiley   +1 more source

Adult-onset hypophosphatasia diagnosed after consecutive tooth loss during orthodontic treatment: a case report

Journal of Medical Case Reports
Background Adult hypophosphatasia is an uncommon inherited disorder of mineral homeostasis affecting bone. It arises from mutations within the Alkaline Phosphatase, Biomineralization Associated (ALPL) gene, which encodes tissue-nonspecific alkaline ...
Shusuke Tokuchi, Toshihiro Kawano, Edward Hosea Ntege, Makoto Murahashi, Kentaro Ide, Nobuyuki Maruyama, Risako Suzuki, Mirei Takai-Nabeta, Tsuyoshi Nabeta, Hideo Tanaka, Yusuke Shimizu, Hiroyuki Nakamura   +11 more
doaj   +1 more source

Hypophosphatasia: A Novel Mutation Associated with an Atypical Newborn Presentation

JCRPE, 2020
Hypophosphatasia, a rare genetic disease affecting bone metabolism, is characterized by decreased activity of tissue non-specific alkaline phosphatase (TNAP).
Roger Esmel-Vilomara, Susana Hernández, Ariadna Campos-Martorel, Eva González-Roca, Diego Yeste, Félix Castillo   +5 more
doaj   +1 more source

Pathological Ossification of Spinal Ligament‐Derived Fibroblasts in an Inflammatory Micro‐Environment via Activation of the ECM/ITGA5/FAK/AKT Pathway in Ankylosing Spondylitis

Cell Proliferation, EarlyView.
Schematic diagram illustrating the activation of the ECM/ITGA5/FAK/AKT axial signalling pathway in the osteogenic transdifferentiation of AS ligaments‐derived fibroblasts and the simulation of ectopic ossification via subcutaneous transplantation in vivo.
Mu Qiao, Kai‐Yang Wang, Chen‐Yu Song, Jing‐Shun Lu, Jiu‐Kun Li, Yong Qiu, Bang‐Ping Qian, Ze‐Zhang Zhu   +7 more
wiley   +1 more source

Cranial Neural Crest Specific Deletion of Alpl (TNAP) via P0-Cre Causes Abnormal Chondrocyte Maturation and Deficient Cranial Base Growth

, 2023
Bone growth plate abnormalities and skull shape defects are seen in hypophosphatasia, a heritable disorder in humans that occurs due to the deficiency of tissue nonspecific alkaline phosphatase (TNAP, Alpl) enzyme activity.
Nan Hatch, Fei Liu, Hwa Kyung Nam, Naoto Ohkura   +3 more
core   +1 more source

Hypophosphatasia: current concepts in diagnosis and management of a rare metabolic disorder [PDF]

Exploration of Musculoskeletal Diseases
Hypophosphatasia (HPP) is a rare inherited metabolic disorder caused by deficient activity of tissue non-specific alkaline phosphatase (TNSALP). The resulting accumulation of its substrates, particularly inorganic pyrophosphate (PPi) and pyridoxal-5 ...
Maritza Vidal, Tiara Gill, Richard Keen, Judith Bubbear   +3 more
doaj   +1 more source