Results 71 to 80 of about 10,834 (202)

Atrophic Skeletal Muscle‐Derived Extracellular Vesicles Transfer miR‐125a‐5p to Inhibit Bone Formation in Osteoporosis during Aging

Advanced Science, EarlyView.
A muscle‐bone endocrine pathway in aging is revealed in which extracellular vesicles released from atrophic skeletal muscle (Aged‐SKM‐EVs) inhibit bone formation. These EVs deliver miR‐125a‐5p to osteoblasts, thereby suppressing the SIRT7‐Sp7 signaling axis and osteogenic differentiation.
Xiaoyan Shao, Pan Zhang, Zhidan Fan, Jiaquan Lin, Xiang Chen, Na Liu, Wang Gong, Yi He, Yining Zhou, Tianshu Shi, Yong Shi, Yuze Ma, Wentian Gao, Haosheng Wang, Depeng Fang, Chengzhi Wang, Wenshu Wu, Wenjin Yan, Jianghui Qin, Dongyang Chen, Haiguo Yu, Qing Jiang, Baosheng Guo   +22 more
wiley   +1 more source

Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis [PDF]

, 2014
Objectives: To investigate how the genetic susceptibility gene DIO2 confers risk to osteoarthritis (OA) onset in humans and to explore whether counteracting the deleterious effect could contribute to novel therapeutic approaches.
Akker, E.B. (Erik) van den, Bomer, N. (Nils), Bos, S.D. (Steffan), Breggen, R. (Ruud) van der, Darvishan, A. (Arash), Duijnisveld, B.J. (Bouke), Eeden, A.E. (Annelies) van, Heijmans, B.T. (Bastiaan), Hollander, W. (Wouter) den, Lakenberg, N. (Nico), Meulenbelt, I. (Ingrid), Nelissen, R.G.H.H. (Rob), Osch, G.J.V.M. (Gerjo) van, Pepers, B.A. (Barry), Ramos, Y.F.M. (Yolande), Roon-Mom, W.M.C. (Willeke) van, Slagboom, P.E. (Eline), Tobi, E.W. (Elmar), Verbeek, F.J. (Fons)   +18 more
core   +1 more source

ZMAT1 Promotes Osteoclastogenesis Through TRIM46 Mediated YAP1 Degradation and Inhibits Osteoblastogenesis

Advanced Science, EarlyView.
Zmat1 deficiency mitigates pathological bone loss by impairing osteoclastogenesis and promoting osteoblastogenesis. Mechanistically, in osteoclasts, Zmat1 loss relieves transcriptional repression of the E3 ligase TRIM46, promoting YAP1 degradation and inhibiting osteoclastogenic genes.
Xinyu Chang, Yijin Hou, Likun Cui, Huiqi Yu, Rong Liu, Junhao Sui, Zhong Zheng, Lu Liu, Jie Chen, Mengchen Chen, Chen Ding, Shuogui Xu, Sheng Xu, Hao Zhang   +13 more
wiley   +1 more source

The Effect of Asfotase Alfa on Plasma and Urine Pyrophosphate Levels and Pseudofractures in a Patient With Adult‐Onset Hypophosphatasia

JBMR Plus, 2023
Hypophosphatasia (HPP) is an inherited disease caused by variants of the ALPL gene encoding tissue‐nonspecific alkaline phosphatase. Adult‐onset HPP (adult HPP), known as a mild form of HPP, develops symptoms involving osteomalacia after the age of 18 ...
Naoko Hidaka, Hiroaki Murata, Kanako Tachikawa, Keiichi Osaki, Takashi Sekiyama, Yuka Kinoshita, Hajime Kato, Yoshitomo Hoshino, Soichiro Kimura, Takashi Sunouchi, So Watanabe, Masaomi Nangaku, Noriko Makita, Toshimi Michigami, Nobuaki Ito   +14 more
doaj   +1 more source

Osteocytes Serve as a Progenitor Cell of Osteosarcoma [PDF]

, 2014
Osteosarcoma (OSA) is the most common primary bone tumor in humans. However, the cell of origin of OSA is not clearly defined although there is evidence that osteoblasts may serve as OSA progenitors.
Asai, Atkin, Baird, Barger, Barroga, Bellahcene, Berman, Bielack, Bielack, Bonewald, Cao, Czekanska, Fan, Fogh, Franz-Odendaal, Henderson, Jones, Kashima, Kato, Khanna, Kimura, Knowles, Kobayashi, Kunita, Lane, Lednicky, Lee, Levine, Marton, Mohseny, Mutsaers, Patane, Pautke, Pipas, Qin, Rhodes, Rodan, Schmidt, Sottnik, Sottnik, Su, Walkley, Wijenayaka, Woo, Wysolmerski, Ye, Yin, Yu, Zhang, Zhu   +49 more
core   +1 more source

Multifunctional Bioactive Scaffold Facilitating BMSCs‐Driven Osteogenesis and Vascularization in Critical‐Sized Bone Defect Repair

Advanced Science, EarlyView.
A dual‐network bFGF@CB‐gel integrates: i) ChSMA scaffold (mechanical support/BMSCs delivery); ii) BC carrier (sustained bFGF release via EGFL/Itga2b and COMP/PI3K/AKT for adhesion/osteogenesis); iii) bFGF/PI3K/AKT/eNOS for angiogenesis. This rational, synergistic design addresses CSD bone regeneration challenges.
Yunze Feng, Bingzhi Chen, Yu Xu, Xin Xu, Bingtao Hu, Tongbo Li, Dingxin Zhang, Baoshuai Bai, Chen Liu, Wanlong Xu, Le Li, Wencan Zhang, Haipeng Si   +12 more
wiley   +1 more source

Generation of a new human iPSC cell line (UOMi010-A) from a patient with hypophosphatasia

Stem Cell Research
Hypophosphatasia (HPP) is characterized by loss of function variants in the alkaline phosphatase (ALPL) gene that leads to impaired mineralization in bones and teeth.
Abhay Srivastava, Dylan Walker, Jason Uzonna, Cheryl Rockman-Greenberg, Sanjiv Dhingra   +4 more
doaj   +1 more source

The effect of hormone replacement therapy on the expression of the alkaline phosphatase gene (ALPL) within the mucosal epithelium of the cheek and in peripheral blood lymphocytes

Current Issues in Pharmacy and Medical Sciences, 2014
In adult life, proper bone metabolism requires efficient regulation of bone formation and resorption processes. Bone turnover markers allow for assessing the rate of bone formation and resorption processes.
Rahnama Mansur, Lobacz Michal, Szyszkowska Anna, Trybek Grzegorz, Kozicka-Czupkallo Maryla   +4 more
doaj   +1 more source

Fibroblasts from patients affected by Pseudoxanthoma elasticum exhibit an altered PPi metabolism and are more responsive to pro-calcifying stimuli [PDF]

, 2014
BACKGROUND: Pseudoxanthoma elasticum (PXE) is a genetic disorder characterized by progressive calcification of soft connective tissues. The pathogenesis is still hard to pin down.
ANNOVI, Giulia, BARTOLOMEO, ANGELICA, BORALDI, Federica, QUAGLINO, Daniela   +3 more
core   +1 more source

Clinical and ALPL Gene Mutations Analysis in an Early Onset Chinese Odontohypophosphatasia Patient

American Journal of Biomedical Sciences, 2014
Objective: To describe a Chinese case with novel frame shift ALPL gene mutation that results in infantile onset odontohypophosphatasia. Methods: Clinical data and genomic DNA of the patient and his parents were collected. Alkaline phosphatase gene (ALPL)of the patient and his parents were PCR following with sequencing.
Xuejun Liang, Min Liu, Chunxiu Gong
openaire   +1 more source