Results 161 to 170 of about 2,287,133 (314)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Mechanism of <i>Echinochloa crus-galli</i> Resistance to the ALS-Inhibiting Herbicide Pyrazosulfuron-ethyl in China. [PDF]

Plants (Basel)
Liu Q, Zhang R, Sun L, Lu X, Xu G, Tong H, Zhang B, Liu X, Du S.   +8 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Innate immune crosstalk in ALS/FTD pathogenesis. [PDF]

Cell Insight
Shu X, Yu X, Xu P, Wang A.
europepmc   +1 more source

Mutations in the tail and rod domains of the neurofilament heavy-chain gene increase the risk of ALS [PDF]

Objective: Neurofilament heavy-chain gene (NEFH) variants are associated with multiple neurodegenerative diseases, however, their relationship with ALS has not been robustly explored. Still, NEFH is commonly included in genetic screening panels worldwide.
Morrison, Karen E, Veldink, Jan H, Corcia, Philippe, McLaughlin, Russell, Cooper-Knock, Johnathan, Al-Chalabi, Ammar, Gotkine, Marc, Pardina, Jesús S Mora, Vourc'h, Patrick, Andersen, Peter M, Shaw, Christopher E, van den Berg, Leonard H, Başak, Nazli A, van Damme, Philip, Spargo, Thomas P, Couratier, Philippe, Marriott, Heather, Landers, John E, Dobson, Richard J, Weber, Markus, Shaw, Pamela J, Pinto, Susana, Drory, Vivian, Iacoangeli, Alfredo, Project MinE ALS Sequencing Consortium, Silani, Vincenzo, Ticozzi, Nicola, Schwab, Patrick, de Carvalho, Mamede, Al Khleifat, Ahmad   +29 more
core  

IMPACT ALS - Investigation and Measuring Patient and Caregiver Trends About ALS

IMPACT ALS Survey questionnaires and raw ...
The ALS Association
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A rare missense variant impacting NEK1 kinase function is associated with ALS. [PDF]

Acta Neuropathol Commun
Brenner D, Ponomarenko A, Petrut I, Beyrle S, Contardo M, Loss I, Radke C, Frank J, Zimmer E, Schlesner M, Achenbach P, Scheveneels W, Aly A, Nazlican H, Hesebeck-Brinkmann J, Oeckl P, Müller K, Siebert R, Böckers T, van Eijk K, Veldink J, Kleger A, Mulaw M, Andersen PM, Forsberg K, Weishaupt JH, Loghmani SB, Grehl T, van Damme P, Weis J, Catanese A.   +30 more
europepmc   +1 more source

The ALSFRS-R Summit: a global call to action on the use of the ALSFRS-R in ALS clinical trials [PDF]

The Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS) was developed more than 25 years ago as an instrument to monitor functional change over time in patients with ALS.
Genge, Angela, Andrews, Jinsy, Van Damme, Philip, Couillard, Mathias, Fournier, Christina, Shefner, Jeremy, Cedarbaum, Jesse M., McDermott, Chris, Polzer, John, Salmon, Kristiana, Berry, James, Al-Chalabi, Ammar, Grosskreutz, Julian, Kittle, Gale, Bertone, Vanessa, Bunte, Tommy M., van Eijk, Ruben P.A., van den Berg, Leonard H., Straub, Corey, Chio, Adriano, Glass, Jonathan, Cummings, Cathy   +21 more
core