Results 221 to 230 of about 29,954 (264)

Effects of two new aldose reductase inhibitors, AL-1567 and AL-1576, in diabetic rats

Metabolism, 1987
Two new potent aldose reductase inhibitors, AL-1567 (DL-spiro(2-fluoro-9H-fluoren-9,4'-imidazolidine)-2',5'-dione) and AL-1576 (spiro-(2,7-difluoro-9H-fluoren-9,4'-imidazolidine)2',5'-dione), have been characterized with respect to in vitro activity toward rat lens and human placental aldose reductase and in vivo activity in uncontrolled, severely ...
B W, Griffin, L G, McNatt, M L, Chandler, B M, York   +3 more
openaire   +2 more sources

Zimt als Inhibitor der Speichelamylase

Lebensmittelchemie, 2022
D. Beranek, J. Vogel, A. Hellwig, T. Henle   +3 more
openaire   +1 more source

A novel Pro197Glu substitution in acetolactate synthase (ALS) confers broad-spectrum resistance across ALS inhibitors

Pesticide Biochemistry and Physiology, 2015
Water chickweed (Myosoton aquaticum L.), a competitive broadleaf weed, is widespread in wheat fields in China. Tribenuron and pyroxsulam failed to control water chickweed in the same field in Qiaotian Village in 2011 and 2012, respectively. An initial tribenuron resistance confirmation test identified a resistant population (AH02).
Weitang, Liu, Guohui, Yuan, Long, Du, Wenlei, Guo, Lingxu, Li, Yaling, Bi, Jinxin, Wang   +6 more
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Targeting FUS-ALS aggregation with Proteasome Inhibitors

Summary ALS, Amyotrophic lateral sclerosis, a devastating neurodegenerative disease (ND) with no cure, is often caused by abnormal cytosolic aggregation of RNA-binding proteins, the most well-known of which are TDP-43 and FUS. The proteasome is considered one of the major systems that degrades misfolded, including ND-associated ...
Amal Younis, Kanar Yassen, Kinneret Rozales, Tahani Kadah, Naseeb Saida, Anatoly Meller, Joyeeta Dutta Hazra, Ronit Heinrich, Flonia Levy-Adam, Shai Berlin, Reut Shalgi   +10 more
openaire   +1 more source

Proteasome inhibitors in AL amyloidosis: focus on mechanism of action and clinical activity

Hematological Oncology, 2016
AbstractProteasome inhibitors are the backbone in the treatment of multiple myeloma with 3 of its representatives (bortezomib, carfilzomib, and ixazomib) having already been approved. There is a different situation altogether in the treatment of amyloid light chain (AL) amyloidosis where owing to the rarity of this entity neither of these drugs has ...
T, Jelinek, E, Kryukova, Z, Kufova, F, Kryukov, R, Hajek   +4 more
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Hesperidinphosphat als Hyaluronidaseinhibitor

Klinische Wochenschrift, 1954
Mit Hilfe der Cantharidenblasenmethode und der Capillarresistometrie ist es moglich, den Effekt des Hesperidinphosphats auf die Eiweis- und Erythrocytendurchlassigkeit der Capillarwandschranke statistisch wahrscheinlich zu machen.
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Basis of ACCase and ALS inhibitor resistance in Hordeum glaucum Steud

Pest Management Science, 2017
AbstractBACKGROUNDAcetyl coenzyme‐A carboxylase (ACCase) and/or acetolactate synthase (ALS) inhibitor resistance has been identified by herbicide resistance screening in eight populations obtained from cropping regions of South Australia. This study aimed to quantify the level of resistance and characterise the molecular basis of resistance to ACCase ...
Lovreet S, Shergill, Jenna, Malone, Peter, Boutsalis, Christopher, Preston, Gurjeet, Gill   +4 more
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Research Progress of ALS and ALS Inhibitors Herbicides

Botanical Research, 2021
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Proteasome Inhibitors in the Treatment of Multiple Myeloma and AL Amyloidosis

2014
Therapeutic advances in the last decade have led to improved outcomes for people diagnosed with multiple myeloma (MM) and primary systemic (AL) amyloidosis. Foremost among these advances is the incorporation of proteasome inhibitors (PIs) and immunomodulatory drugs (IMiDs) into treatment regimens. Induction regimens for MM which incorporate one or both
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A New Binding Model for Structurally Diverse ALS Inhibitors

Pesticide Science, 1996
Acetolactate synthase (ALS) has been a very attractive target for herbicides for the last decade. There are several ALS inhibitors in commercial use spanning the world-wide market. In this study, the common structural features within a subset of ALS inhibitors were investigated by molecular graphics and quantum chemical calculations.
openaire   +1 more source