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Aggregation of trypsin and trypsin inhibitor by Al cation
Journal of Photochemistry and Photobiology B: Biology, 2017Al cation may trigger protein structural changes such as aggregation and fibrillation, causing neurodegenerative diseases. We report the effect of Al cation on the solution structures of trypsin (try) and trypsin inhibitor (tryi), using thermodynamic analysis, UV-Visible, Fourier transform infrared (FTIR) spectroscopic methods and atomic force ...
P, Chanphai +2 more
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The design and synthesis of ALS inhibitors from pharmacophore models
Bioorganic & Medicinal Chemistry Letters, 1999In search of new ALS inhibitors without the previous knowledge of receptor crystal structure, DISCO module was applied to produce 3D-pharmacophore models, which provided information to design novel molecules by 3D-database searching. Then a number of molecules were synthesized. Several of them have some ALS inhibitory activities.
J, Liu, Z, Li, H, Yan, L, Wang, J, Chen
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Natriumbenzoat als Korrosions‐Inhibitor in wäßrigen Dispersionen
Materials and Corrosion, 1957AbstractEs wird untersucht, inwieweit die Emballage von wäßrigen Anstrichdispersionen durch Natriumbenzoatzusäte vor Korrosion geschützt werden kann. Anhand von Versuchen und Beispielen wird die Korrosionsschutzwirkung von Natrium‐benzoat allein wie auch im Gemisch mit Natriumnitrit gezeigt.
H.‐J. Freier, W. Geilenkirchen
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Common lambsquarters response to the ALS inhibitor herbicides
Research on Crops, 2019Common lambsquarters (Chenopodium album) is a worldwide weed species growing in cropping system. Two trials were performed between 2015 and 2016 to evaluate applications of ALS inhibitor herbicides for common lambsquarters control and crop safety in spring wheat.
Pliushchikov V. +5 more
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Physiological consequences of mutation for ALS-inhibitor resistance
Weed Science, 1999Biochemical and physiological effects of target site resistance to herbicides inhibiting acetolactate synthase (ALS) were evaluated using sulfonylurea-resistant (R) and -susceptible (S) near isonuclearLactuca sativa‘Bibb’ lines derived by backcrossing the resistance allele fromLactuca serriolaL. intoL.
Charlotte V. Eberlein +7 more
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Effects of two new aldose reductase inhibitors, AL-1567 and AL-1576, in diabetic rats
Metabolism, 1987Two new potent aldose reductase inhibitors, AL-1567 (DL-spiro(2-fluoro-9H-fluoren-9,4'-imidazolidine)-2',5'-dione) and AL-1576 (spiro-(2,7-difluoro-9H-fluoren-9,4'-imidazolidine)2',5'-dione), have been characterized with respect to in vitro activity toward rat lens and human placental aldose reductase and in vivo activity in uncontrolled, severely ...
B W, Griffin +3 more
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Research Progress of ALS and ALS Inhibitors Herbicides
Botanical Research, 2021openaire +1 more source
Targeting FUS-ALS aggregation with Proteasome Inhibitors
Summary ALS, Amyotrophic lateral sclerosis, a devastating neurodegenerative disease (ND) with no cure, is often caused by abnormal cytosolic aggregation of RNA-binding proteins, the most well-known of which are TDP-43 and FUS. The proteasome is considered one of the major systems that degrades misfolded, including ND-associated ...Amal Younis +10 more
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Proteasome Inhibitors in the Treatment of Multiple Myeloma and AL Amyloidosis
2014Therapeutic advances in the last decade have led to improved outcomes for people diagnosed with multiple myeloma (MM) and primary systemic (AL) amyloidosis. Foremost among these advances is the incorporation of proteasome inhibitors (PIs) and immunomodulatory drugs (IMiDs) into treatment regimens. Induction regimens for MM which incorporate one or both
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