Results 151 to 160 of about 2,396,315 (311)

Resistance to ALS inhibitors in rice in north-western Italy

, 1999
In Europe, 10 weed species have developed resistance to acetolactate synthase (ALS) inhibiting herbicides. Currently, the most serious problems with ALS resistance are found in paddy rice.
Tabacchi M, Sattin M, Zanin G, Berto D
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Characterization of ALS Patient iPSC-Derived Motor Neurons

Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressing fatal neurodegenerative disease. It is characterized by motor neuron (MN) degeneration, which leads to the loss of voluntary movement control and premature mortality.
Reynolds, Paige
core  

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Evaluating the effect of a new inhibitor of USP14 in a Drosophila model of ALS [PDF]

openProtein and organelle homeostasis (proteostasis) comprises the cellular mechanisms responsible for maintaining protein and organelle stability, which is essential for cell physiology and proper function.
LUCIANO, SONIA
core  

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Quinoxaline-Based Inhibitors of Malarial Protease PfSUB1

2,3-Bis(phenylamino)quinoxalines have been identified as a novel class of malarial protease PfSUB1 inhibitors by screening of Malaria Box compounds.
Blackman, M. J., Penzo, M., Fulle, S., Ebejer, J. P., Jirgensons, Aigars, Finn, P. W., Kher, Samir Satish   +6 more
core  

Guidance for clinical management of pathogenic variant carriers at elevated genetic risk for ALS/FTD [PDF]

There is a growing understanding of the presymptomatic stages of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) and nascent efforts aiming to prevent these devastating neurodegenerative diseases have emerged.
Dratch, Laynie, Shefner, Jeremy, Cooper-Knock, Johnathan, Al-Chalabi, Ammar, Arias, Jalayne J., Heiman-Patterson, Terry D., Turner, Martin R., Westeneng, Henk Jan, Vinceti, Marco, Brickman, Daniel, Goutman, Stephen A., Swidler, Jean, Benatar, Michael, van den Berg, Leonard H., Casaletto, Kaitlin B., Attendees of the Workshop on Guidance for Clinical Care of People Living with a Pathogenic Variant At-Risk for ALS and FTD   +15 more
core  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source