Results 241 to 250 of about 2,396,315 (311)

Mitochonic acid 5 alleviates amyotrophic lateral sclerosis phenotypes via mitochondrial augmentation. [PDF]

JCI Insight
Oikawa Y, Luo Y, Suzuki N, Kasahara T, Tongu Y, Yoshida Y, Tominari T, Tanabe S, Suto Y, Kashiwagi H, Saito S, Ikeda K, Suzuki C, Kuranaga A, Akiyama T, Morimoto S, Aoki Y, Muramatsu R, Soga T, Aoki M, Okano H, Tanaka T, Abe T, Kuranaga E, Toyohara T.   +24 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Protease-Mediated TAR DNA-Binding Protein 43 (TDP-43) Pathogenesis: From Molecular Mechanisms to Therapeutic Opportunities. [PDF]

ACS Pharmacol Transl Sci
Xavier J, Singh M, Tamhankar S, Griffett K, Amin R.   +4 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Agronomic drivers of Tribenuron-methyl resistance in wild mustard (Sinapis arvensis) in dryland wheat fields of western Iran. [PDF]

PLoS One
Moradi F, Bagheri A, Mondani F, Nosratti I.   +3 more
europepmc   +1 more source

Liquid nitrogen as an adjuvant to ALS-inhibitors

, 2019
openaire   +1 more source

ADAR-mediated RNA editing in CNS disorders: from pathogenic mechanisms to therapeutic opportunities. [PDF]

Cell Mol Biol Lett
Zheng F, Guan R, Yu X, Yang J, Zhao H, Yang F.   +5 more
europepmc   +1 more source

Lichen sclerosus. Part 2. Guideline of the DGG, DGGG, OEGGG and SGGG (S3-Level, AWMF Registry No. 013-105, July 2025. [PDF]

Geburtshilfe Frauenheilkd
Kirtschig G, Woelber L, Kinberger M, Becker K, Ciresa-König A, Fischer B, Fricke-Otto S, Günther C, Hirchenhain C, Köllmann NH, Kreuter A, Malisiewicz B, Neis F, O'Dey DM, Ott H, Promm M, Renner R, Schardt AR, Schweizer I, Stein R, Ter-Nedden J, Trutnovsky G, Wand A, Weyandt G, Werner RN, Günthert A.   +25 more
europepmc   +1 more source

Familial, neuropathological and cellular analysis identify ARPP21 as a major amyotrophic lateral sclerosis associated gene in French cohorts. [PDF]

Acta Neuropathol
de Bertier S, Amador MD, Guissart C, Miki T, Boillée S, Lobsiger CS, Bohl D, Fauret-Amsellem AL, Bohic A, Brainbank Neuro-CEB neuropathology network, Giguet-Valard AG, Bellance R, Beauvais K, Meininger V, Bruneteau G, Salachas F, Vial C, Camu W, Esselin F, de la Cruz E, Bernard E, Seilhean D, Millecamps S.   +22 more
europepmc   +1 more source

Histone modification dynamics in brain aging: unlocking therapeutic potential. [PDF]

Cell Death Dis
Chang B, Yang S, Yilixiati A, Zhang F, Sun X, Wang L, Hu B, Zhou Y.   +7 more
europepmc   +1 more source