Results 41 to 50 of about 2,414,840 (255)
Target-site resistance to ALS inhibitors in the polyploid species Echinochloa crus-galli
, 2013 Acetolactate synthase (ALS) inhibitors are widely used herbicides in rice and their recurrent use has resulted in several resistant weed populations.
Tranel PJ +3 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider +15 more
wiley +1 more source
Identification of acetolactate synthase resistant Amaranthus retroflexus in Ukraine
Regulatory Mechanisms in Biosystems, 2022 The problem of weed resistance to herbicides has become very important in the last decade and threatens to dramatically reduce the productivity and profitability of modern crop production. Herbicides – ALS inhibitors dominate among current herbicides and
L. M. Mykhalska, V. V. Schwartau
doaj +1 more source
Running Title: CDC-7 inhibitors correct TDP-43 pathology in ALS and FLTD
, 2020 38 p.-7 fig.-2 tab.TDP-43 has been identified as the major component of protein aggregates found in affected neurons in FTLD-TDP and ALS patients. TDP-43 is hyperphosphorylated,ubiquitinated and cleaved in the C-terminus.
Elisa Rojas‐Prats +17 more
core +1 more source
Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids
Pediatric Blood &Cancer, EarlyView.ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz +12 more
wiley +1 more source
Novel Reversible Inhibitors of Xanthine Oxidase Targeting the Active Site of the Enzyme
Antioxidants, 2023 Xanthine oxidase (XO) is a flavoprotein catalysing the oxidation of hypoxanthine to xanthine and then to uric acid, while simultaneously producing reactive oxygen species.
Rosario Rullo +6 more
doaj +1 more source
Discovery and validation of SIRT2 inhibitors based on tenovin-6 : use of a 1H-NMR method to assess deacetylase activity [PDF]
, 2012 The search for potent and selective sirtuin inhibitors continues as chemical tools of this type are of use in helping to assign the function of this interesting class of deacetylases.
Pirrie, L +29 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben +4 more
wiley +1 more source
Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin +17 more
wiley +1 more source
EBioMedicine, 2019 Background: Histone deacetylase 4 (HDAC4) has been proposed as a target for Amyotrophic Lateral Sclerosis (ALS) because it mediates nerve-skeletal muscle interaction and since its expression in skeletal muscle correlates with the severity of the disease.
Eva Pigna +8 more
doaj +1 more source