Results 241 to 250 of about 2,502,365 (304)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Intron retention in health and amyotrophic lateral sclerosis. [PDF]

Brain
Wang CY, Taylor S, Pandya VA, Clarke BE, Pal K, Shelkovnikova TA, Wang Y, Luisier R, Patani R.   +8 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Peripheral TDP-43 pathology in amyotrophic lateral sclerosis: toward a systemic proteinopathy. [PDF]

Acta Neuropathol
Codron P, Miranda M, Garnier M, He S, Gouju J, Cassereau J, Leblanc P, Letournel F.   +7 more
europepmc   +1 more source

Liquid nitrogen as an adjuvant to ALS-inhibitors

, 2019
openaire   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Self-resistance as a guide to discovering bioactive natural products. [PDF]

Curr Opin Chem Biol
Liu C, Zhang W.
europepmc   +1 more source

TBK1 eliminates aggregation-prone monomeric TDP-43 through an IFNβ-immunoproteasome pathway in ALS models. [PDF]

EMBO Rep
Sakai S, Oiwa K, Iguchi Y, Akcay IM, Watanabe S, Komine O, Nagata N, Horiuchi M, Sreedharan J, Katsuno M, Yamanaka K.   +10 more
europepmc   +1 more source

Integrated In Silico Discovery of Thymoquinone Analogs Targeting the Keap1-Nrf2 Pathway for Amyotrophic Lateral Sclerosis Therapy. [PDF]

ChemistryOpen
Nalicho JC, Mabeyo PE, Paluch AS, Paul L.   +3 more
europepmc   +1 more source

Proteostasis (in)action: the role of co-pathologies in neurodegenerative disease. [PDF]

Philos Trans R Soc Lond B Biol Sci
Morley JF.
europepmc   +1 more source