Results 241 to 250 of about 2,388,646 (309)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Electron-withdrawing group effects on the structural, electronic, reactivity, and binding characteristics of triazolopyrimidine herbicides: a comparative study of diclosulam, cloransulam-methyl, and cloransulam. [PDF]

RSC Adv
Potla KM, Justin Nathaniel CM, Parameshwar Adimule S, Vincent Raj Shanthi JR, Bilal H, Tawfeek AM, Islam MS.   +6 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Phase separation in neurodegenerative disorders: a metabolic perspective on protein aggregation and therapeutic targeting. [PDF]

Transl Neurodegener
Peng S, Chen H, Yin G, Verkhratsky A, Yi C.   +4 more
europepmc   +1 more source

Liquid nitrogen as an adjuvant to ALS-inhibitors

, 2019
openaire   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

The centrosome-cilium-centriolar satellite axis in neurodegenerative diseases. [PDF]

EMBO Rep
Sahin U, Firat-Karalar EN.
europepmc   +1 more source

The role of AI-assisted drug repurposing in neurological disorders: a systematic review of validation strategies, challenges and opportunities. [PDF]

J Nanobiotechnology
Chen F, Wang L, Liu H, Khan Q, Tang B, Bao N.   +5 more
europepmc   +1 more source

P2X7 Receptor in Rare Diseases: Shared Molecular Mechanisms and Therapeutic Implications. [PDF]

J Inflamm Res
Xiao X, Cao G, Hou S, Yin H.
europepmc   +1 more source

Astrocytes in Neurodegeneration: Spatial States, Crosstalk, and Emerging Therapies. [PDF]

Mol Neurobiol
Steger L, Rothhammer V, Zunke F.
europepmc   +1 more source