Results 201 to 210 of about 24,992 (265)

Histone modification dynamics in brain aging: unlocking therapeutic potential. [PDF]

Cell Death Dis
Chang B, Yang S, Yilixiati A, Zhang F, Sun X, Wang L, Hu B, Zhou Y.   +7 more
europepmc   +1 more source

Therapeutic Challenges and Future Breakthroughs in Amyotrophic Lateral Sclerosis: From Precision Medicine to Innovative Trial Design. [PDF]

Drug Des Devel Ther
Wei Y, Wang J, Ji Y, Shang T, Shen Y, Sun H, Cai Y.   +6 more
europepmc   +1 more source

Oxidative stress and inflammation in neurodegenerative disorders. [PDF]

Arch Toxicol
Jomova K, Alomar SY, Valko R, Nepovimova E, Kuca K, Valko M.   +5 more
europepmc   +1 more source

Efficacy and safety of pharmacological and biological therapies for amyotrophic lateral sclerosis: a network meta-analysis. [PDF]

Front Neurol
Zhou S, Li X, Jiao Y, Wu J.
europepmc   +1 more source

Pridopidine Mediated Sigma-1 Receptor Activation and Therapeutic Implications in Neurodegenerative Diseases. [PDF]

Neurol Int
Anwar AI, Hegazi AA, Bhuchakra HP, Nelson JR, Birdsong TL, Fontenot CJ, Zeibo M, Fazal-Ur-Rehman MM, Bieber HP, Spring CJ, Smith JL, Hachem IA, Singh T, Sawaya MF, Murnane KS, Kaye AD.   +15 more
europepmc   +1 more source

The role of AI-assisted drug repurposing in neurological disorders: a systematic review of validation strategies, challenges and opportunities. [PDF]

J Nanobiotechnology
Chen F, Wang L, Liu H, Khan Q, Tang B, Bao N.   +5 more
europepmc   +1 more source

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Aggregation of trypsin and trypsin inhibitor by Al cation

Journal of Photochemistry and Photobiology B: Biology, 2017
Al cation may trigger protein structural changes such as aggregation and fibrillation, causing neurodegenerative diseases. We report the effect of Al cation on the solution structures of trypsin (try) and trypsin inhibitor (tryi), using thermodynamic analysis, UV-Visible, Fourier transform infrared (FTIR) spectroscopic methods and atomic force ...
P, Chanphai, L, Kreplak, H A, Tajmir-Riahi   +2 more
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The design and synthesis of ALS inhibitors from pharmacophore models

Bioorganic & Medicinal Chemistry Letters, 1999
In search of new ALS inhibitors without the previous knowledge of receptor crystal structure, DISCO module was applied to produce 3D-pharmacophore models, which provided information to design novel molecules by 3D-database searching. Then a number of molecules were synthesized. Several of them have some ALS inhibitory activities.
J, Liu, Z, Li, H, Yan, L, Wang, J, Chen
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Natriumbenzoat als Korrosions‐Inhibitor in wäßrigen Dispersionen

Materials and Corrosion, 1957
AbstractEs wird untersucht, inwieweit die Emballage von wäßrigen Anstrichdispersionen durch Natriumbenzoatzusäte vor Korrosion geschützt werden kann. Anhand von Versuchen und Beispielen wird die Korrosionsschutzwirkung von Natrium‐benzoat allein wie auch im Gemisch mit Natriumnitrit gezeigt.
H.‐J. Freier, W. Geilenkirchen
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