Results 11 to 20 of about 112,092 (264)

Janus kinase inhibitors are potential therapeutics for amyotrophic lateral sclerosis

Translational Neurodegeneration, 2023
Amyotrophic lateral sclerosis (ALS) is a poorly treated multifactorial neurodegenerative disease associated with multiple cell types and subcellular organelles.
Peter J. Richardson, Daniel P. Smith, Alex de Giorgio, Xenia Snetkov, Joshua Almond-Thynne, Sara Cronin, Richard J. Mead, Christopher J. McDermott, Pamela J. Shaw   +8 more
doaj   +1 more source

Lessons from LIMK1 enzymology and their impact on inhibitor design [PDF]

, 2019
LIM domain kinase 1 (LIMK1) is a key regulator of actin dynamics. It is thereby a potential therapeutic target for the prevention of fragile X syndrome and amyotrophic lateral sclerosis.
Beltrami, A, Bullock, Alexander, Canning, P, Chaikuad, A, Chatterjee, D, Knapp, S, Knaus, P, Mathea, S, Preuss, F, Salah, E, Tumber, A   +10 more
core   +2 more sources

The effect of low growth temperature on Hill reaction and Photosystem 1 activities in three biotypes of Kochia scoparia (L.) Schrad. with different sensitivity to atrazine and ALS-inhibiting herbicides

Plant, Soil and Environment, 2004
A possible influence of low growth temperature on the photochemical activity of isolated mesophyll chloroplasts was studied in three biotypes of kochia [Kochia scoparia (L.) Schrad.] that showed either double resistance to both atrazine and acetolactate ...
D. Holá, M. Kočová, O. Rothová, D. Chodová, J. Mikulka   +4 more
doaj   +1 more source

Synergistic association of resveratrol and histone deacetylase inhibitors as treatment in amyotrophic lateral sclerosis

Frontiers in Pharmacology, 2022
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease associated with motor neuron degeneration, progressive paralysis and finally death. Despite the research efforts, currently there is no cure for ALS.
Edoardo Parrella, Vanessa Porrini, Ilaria Scambi, Michele M. Gennari, Cristina Gussago, Oluwamolakun Bankole, Marina Benarese, Raffaella Mariotti, Marina Pizzi   +8 more
doaj   +1 more source

Resistance to post-emergent herbicides is becoming common for grass weeds on New Zealand wheat and barley farms.

PLoS ONE, 2021
To estimate the prevalence of herbicide-resistant weeds, 87 wheat and barley farms were randomly surveyed in the Canterbury region of New Zealand. Over 600 weed seed samples from up to 10 mother plants per taxon depending on abundance, were collected ...
Christopher E Buddenhagen, Trevor K James, Zachary Ngow, Deborah L Hackell, M Phil Rolston, Richard J Chynoweth, Matilda Gunnarsson, Fengshuo Li, Kerry C Harrington, Hossein Ghanizadeh   +9 more
doaj   +1 more source

Coordinated actions of microRNAs with other epigenetic factors regulate skeletal muscle development and adaptation [PDF]

, 2017
Epigenetics plays a pivotal role in regulating gene expression in development, in response to cellular stress or in disease states, in virtually all cell types.
Adamo, Sergio, Bianchi, Marzia, Moresi, Viviana, Renzini, Alessandra   +3 more
core   +1 more source

Evolution der Herbizidresistenz in Alopecurus myosuroides und Apera spica-venti im deutschen Getreideanbau der letzten 15 Jahre

Julius-Kühn-Archiv, 2020
Das Vorkommen von Herbizidresistenzen bei Ungräsern nimmt in den letzten 30 Jahren in Deutschland kontinuierlich zu. Dies gilt sowohl für die Anzahl der betroffenen Arten, die regionale Verbreitung, den Resistenzgrad, die Anzahl der Aktivsubstanzen, der ...
Petersen, Jan, Raffel, Hans
doaj   +1 more source

Examination of efficacy and selectivity of herbicides in ALS-tolerant sugar beets

Julius-Kühn-Archiv, 2018
The development of herbicide-tolerant sugar beet varieties offers the possibility to use only herbicides from the group of the aceto-lactate synthase (ALS) inhibitors.
Anja Löbmann, Jan Petersen
doaj   +1 more source

Peroxynitrite activates the NLRP3 inflammasome cascade in SOD1(G93A) mouse model of amyotrophic lateral sclerosis [PDF]

, 2017
Neuroinflammation, characterized by the appearance of reactive microglial and astroglial cells, is one of the several pathogenic mechanisms of amyotrophic lateral sclerosis (ALS), a fast-progressing and fatal neurodegenerative disease.
Adamo, Sergio, Bellezza, Ilaria, Costanzi, Egidia, Grottelli, Silvia, Mezzasoma, Letizia, Minelli, Alba, Moresi, Viviana, Morozzi, Giulio, Peirce, Matthew J., Pigna, Eva, Scarpelli, Paolo   +10 more
core   +1 more source

Potential of plant species for bioremediation of soils applied with imidazolinone herbicides [PDF]

Planta Daninha, 2014
Imidazolinone herbicides present physicochemical characteristics that allow them to persist longer in environment, with increased chances of soil and water contamination, as well as carryover effects on subsequent crops.
L. Galon, A.M. Lima, S. Guimarães, J.G. Belarmino, G.M. Burg, G. Concenço, M.O. Bastiani, A.N. Beutler, R.R. Zandona, A.L. Radünz   +9 more
doaj   +2 more sources