Results 121 to 130 of about 24,040 (262)

Subgenomic Distribution and Herbicide Cross-Resistance of <i>ALS</i> Gene Mutations in Allohexaploid <i>Echinochloa crus-galli</i>. [PDF]

Plant Direct
Cutti L, Turra GM, Machado FM, Sulzbach E, Angonese PS, Markus C, Gaines TA, Merotto A.   +7 more
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Self-resistance as a guide to discovering bioactive natural products. [PDF]

Curr Opin Chem Biol
Liu C, Zhang W.
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Scalable assay to identify inhibitors of prion-like propagation of protein misfolding as potential therapeutics for neurodegeneration. [PDF]

Protein Sci
Narayan A, Neupane K, Woodside MT.
europepmc   +1 more source

Can resistance to ALS-inhibitors be reversed? The PURE approach

, 2013
The widespread use of ALS inhibitors and consequent increase of resistance to this herbicide group prompts new studies on the population dynamics of ALS resistant and susceptible biotypes to check whether the resistance evolution process may be reversed.
Panozzo S, Rosan V, Scarabel L, Sattin M
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Emerging Therapeutic Strategies for Neurodegenerative Diseases: A Comprehensive Review of Recent Advances and Future Directions. [PDF]

Cells
Sepehrimanesh M, Melen SV, Yeasmin F, Ojo VA, Walden F, Urmee H, Etheridge J, Nasu AK.   +7 more
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

An Antifungal with a Novel Mechanism of Action Discovered via Resistance Gene-Guided Genome Mining. [PDF]

ACS Cent Sci
Perlatti B, Vellanki S, Zhang Y, Chiang YM, Hu Y, Yuan M, Dunbar K, Fine A, Grau MF, Li S, O'Donnell T, Shenoy R, Li H, Shi H, Xu X, Chen Z, Arvedson T, Tang Y, Cramer RA, Cee V, Harvey CJB.   +20 more
europepmc   +1 more source