Results 61 to 70 of about 112,765 (306)

TDP-43 loss-of-function causes neuronal loss due to defective steroid receptor-mediated gene program switching in Drosophila [PDF]

, 2013
TDP-43 proteinopathy is strongly implicated in the pathogenesis of amyotrophic lateral sclerosis and related neurodegenerative disorders. Whether TDP-43 neurotoxicity is caused by a novel toxic gain-of-function mechanism of the aggregates or by a loss of
Adachi, Yoshitsugu, Aerts, Stein, Callaerts, Patrick, Chapuis, Julien, Dermaut, Bart, Diaper, Danielle, Dourlen, Pierre, Gistelinck, Marc, Hirth, Frank, Kleinberger, Gernot, Lambert, Jean-Charles, Naval-Sánchez, Marina, Van Broeckhoven, Christine, Vanden Broeck, Lies   +13 more
core   +3 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Causal relationship between PCSK9 inhibitor and common neurodegenerative diseases: A drug target Mendelian randomization study

Brain and Behavior
Background In addition to lowering cholesterol levels, the proprotein convertase subtilis kexin 9 (PCSK9) inhibitor has a variety of effects, including anti‐neuroapoptosis.
Qiang Huang, Qin Zhang, Bei Cao
doaj   +1 more source

An Uncommon Overlap Syndrome Between Ankylosing Spondylitis and Amyotrophic Lateral Sclerosis—Case Report

Medicina
This case report describes an uncommon overlap syndrome between ankylosing spondylitis (AS) and amyotrophic lateral sclerosis (ALS). Initially, the patient was diagnosed with AS, for which he received various specific treatments, including TNF-α ...
Christian Banciu, Sorin Chiriac, Cristina Pojoga, Loredana Marian, Antonio Fabian, Armand Gogulescu, Mihaela Simu, Ramona Parvanescu, Alexandra Mioc, Roxana Racoviceanu, Andreea Munteanu   +10 more
doaj   +1 more source

Resistência de amendoim-bravo aos herbicidas inibidores da enzima acetolactato sintase Wild poinsettia resistance to acetolactate synthase inhibitor herbicides

Planta Daninha, 1999
O controle contínuo de plantas daninhas através da aplicação de herbicidas que apresentam atividade em um único local de ação nas plantas favorece a seleção de biótipos resistentes a estes herbicidas, em certas espécies vegetais.
Ribas A. Vidal, Aldo Merotto Jr.
doaj   +1 more source

Genome-Guided Analysis of Seven Weed Species Reveals Conserved Sequence and Structural Features of Key Gene Targets for Herbicide Development

Frontiers in Plant Science, 2022
Herbicides are commonly deployed as the front-line treatment to control infestations of weeds in native ecosystems and among crop plants in agriculture. However, the prevalence of herbicide resistance in many species is a major global challenge.
Sarah Shah, Sarah Shah, Thierry Lonhienne, Cody-Ellen Murray, Yibi Chen, Yibi Chen, Katherine E. Dougan, Katherine E. Dougan, Yu Shang Low, Craig M. Williams, Gerhard Schenk, Gerhard Schenk, Gerhard Schenk, Gimme H. Walter, Luke W. Guddat, Cheong Xin Chan, Cheong Xin Chan   +16 more
doaj   +1 more source

Statin Use and Risk of Prostate Cancer : A Meta-Analysis of Observational Studies [PDF]

, 2012
Background: Emerging evidence suggests that statins may decrease the risk of cancers. However, available evidence on prostate cancer (PCa) is conflicting.
Dipika Bansal, Fabrizio Schifano, Krishna Undela, Lise Lotte Gluud, Sanjay D'Cruz   +4 more
core   +4 more sources

Inhibition of extracellular regulated kinase (ERK)-1/2 signaling pathway in the prevention of ALS: Target inhibitors and influences on neurological dysfunctions

European Journal of Cell Biology, 2021
Cell signal transduction pathways are essential modulators of several physiological and pathological processes in the brain. During overactivation, these signaling processes may lead to disease progression.
Rakesh Sahu, Shubham Upadhayay, Sidharth Mehan   +2 more
doaj   +1 more source

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

Occurrence and Mechanisms Conferring Multiple Resistance to ALS-Inhibiting and Auxins Mimics Herbicides in Papaver rhoeas from Tunisia

Agronomy
Herbicide-resistant corn poppy (Papaver rhoeas L.) is one of the most important broadleaved weeds and the number of resistant cases is still growing. The aims of this study were to confirm the resistance of P.
Myriem Chtourou, Maria Dolores Osuna, Germán Mora Marín, Zeineb Hada, Joel Torra, Thouraya Souissi   +5 more
doaj   +1 more source