Results 251 to 260 of about 2,388,646 (309)

Targeting MAPK-dependent pathways to modulate reactive astrocyte pathology in neurodegeneration. [PDF]

Commun Biol
Pervaiz I, Blazier AS, Nyarko-Danquah I, Wesseling H, Ramos A, Woodworth L, Taksir TV, Ryan SK, Wirak G, Zhao Z, Hammond TR, Morel C, Bangari DS, Ofengeim D, Rapino F, Hagan N.   +15 more
europepmc   +1 more source

A next-generation HDAC6 inhibitor for amyotrophic lateral sclerosis and frontotemporal dementia. [PDF]

Brain
James RE, Bekier M, Lee PJ, Schroeder FA, Evans LT, Wagner FF, Hickman D, Richardson T, Hatzipetros T, Vieira F, Callizot N, Modi S, Hooker JM, Kranz JE, Brown RH, Barmada SJ, Gilbert TM.   +16 more
europepmc   +1 more source

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Pharmacophore Model of ALS Inhibitors by DISCO Method

Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica, 2000
Miao Fang-Ming, Su Hua-Qing, Wang Jin-Ling, Li Ai-Xiu   +3 more
exaly   +2 more sources

Aggregation of trypsin and trypsin inhibitor by Al cation

Journal of Photochemistry and Photobiology B: Biology, 2017
Al cation may trigger protein structural changes such as aggregation and fibrillation, causing neurodegenerative diseases. We report the effect of Al cation on the solution structures of trypsin (try) and trypsin inhibitor (tryi), using thermodynamic analysis, UV-Visible, Fourier transform infrared (FTIR) spectroscopic methods and atomic force ...
P, Chanphai, L, Kreplak, H A, Tajmir-Riahi   +2 more
openaire   +2 more sources

The design and synthesis of ALS inhibitors from pharmacophore models

Bioorganic & Medicinal Chemistry Letters, 1999
In search of new ALS inhibitors without the previous knowledge of receptor crystal structure, DISCO module was applied to produce 3D-pharmacophore models, which provided information to design novel molecules by 3D-database searching. Then a number of molecules were synthesized. Several of them have some ALS inhibitory activities.
J, Liu, Z, Li, H, Yan, L, Wang, J, Chen
openaire   +2 more sources

Natriumbenzoat als Korrosions‐Inhibitor in wäßrigen Dispersionen

Materials and Corrosion, 1957
AbstractEs wird untersucht, inwieweit die Emballage von wäßrigen Anstrichdispersionen durch Natriumbenzoatzusäte vor Korrosion geschützt werden kann. Anhand von Versuchen und Beispielen wird die Korrosionsschutzwirkung von Natrium‐benzoat allein wie auch im Gemisch mit Natriumnitrit gezeigt.
H.‐J. Freier, W. Geilenkirchen
openaire   +1 more source

Common lambsquarters response to the ALS inhibitor herbicides

Research on Crops, 2019
Common lambsquarters (Chenopodium album) is a worldwide weed species growing in cropping system. Two trials were performed between 2015 and 2016 to evaluate applications of ALS inhibitor herbicides for common lambsquarters control and crop safety in spring wheat.
Pliushchikov V., Bayat M., Zargar M., Akhrarov M., Orujov E., Hassan N.S.   +5 more
openaire   +2 more sources

Physiological consequences of mutation for ALS-inhibitor resistance

Weed Science, 1999
Biochemical and physiological effects of target site resistance to herbicides inhibiting acetolactate synthase (ALS) were evaluated using sulfonylurea-resistant (R) and -susceptible (S) near isonuclearLactuca sativa‘Bibb’ lines derived by backcrossing the resistance allele fromLactuca serriolaL. intoL.
Charlotte V. Eberlein, Mary J. Guttieri, Philip H. Berger, John K. Fellman, Carol A. Mallory-Smith, Donn C. Thill, Roger J. Baerg, William R. Belknap   +7 more
openaire   +1 more source

Effects of two new aldose reductase inhibitors, AL-1567 and AL-1576, in diabetic rats

Metabolism, 1987
Two new potent aldose reductase inhibitors, AL-1567 (DL-spiro(2-fluoro-9H-fluoren-9,4'-imidazolidine)-2',5'-dione) and AL-1576 (spiro-(2,7-difluoro-9H-fluoren-9,4'-imidazolidine)2',5'-dione), have been characterized with respect to in vitro activity toward rat lens and human placental aldose reductase and in vivo activity in uncontrolled, severely ...
B W, Griffin, L G, McNatt, M L, Chandler, B M, York   +3 more
openaire   +2 more sources