Results 111 to 120 of about 2,388,646 (309)

Attention control network impairments in ALS: from anatomy to disconnections [PDF]

openAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder primarily affecting motor function, but a considerable proportion of patients also exhibit cognitive deficits, particularly in attention and executive functioning. These deficits are
GOKULADAS MENON, KARTHIK
core  

Differential effects of low molecular weight inhibitors on the conformation and the immunologic function of the adhesion receptor LFA-1 [PDF]

, 2004
Previous studies of our group 1,2 and by others 3 on the isolated ligand binding domain of LFA-1 (αL I domain) have suggested that some LFA-1 inhibitors act allosterically while other inhibitors were proposed to competitively block the LFA- 1/ligand ...
Welzenbach, Karl Albert
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

International network for ALS research and care (INARC) [PDF]

The International Network for Amyotrophic Lateral Sclerosis (ALS) Research and Care (INARC) was founded in 2022. INARC’s main goals are to offer a platform dedicated to staff members for ALS clinics and research teams who are not physicians. By nurturing
Genge, Angela, Verschoor, Romy L., Bertone, Vanessa, Bunte, Tommy M., Couillard, Mathias, Ingre, Caroline, van den Berg, Leonard H., Straub, Corey, Foucher, Juliette   +8 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

'Pharmacological Treatment of ALS'

, 2014
The Article deals with the Progressive Neurodegenerative Disease ALS. It includes general background on the pathogenesis, clinical features, genetics and epidemiology.
Sakian, Yehonatan
core  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Neuregulin-1 and ALS19 (ERBB4): at the crossroads of amyotrophic lateral sclerosis and cancer

BMC Medicine
Background Neuregulin-1 (NRG1) is implicated in both cancer and neurologic diseases such as amyotrophic lateral sclerosis (ALS); however, to date, there has been little cross-field discussion between neurology and oncology in regard to these genes and ...
Jacob J. Adashek, Chinmayi Pandya, Nicholas J. Maragakis, Pradip De, Philip R. Cohen, Shumei Kato, Razelle Kurzrock   +6 more
doaj   +1 more source