Results 161 to 170 of about 1,055,858 (237)

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Sustainable Hydrogel‐Forming Microneedle‐Reservoir Patches for Transdermal Delivery of Hydrophilic Macromolecules: Biopolymers, Green Manufacturing and Translation

Advanced Science, EarlyView.
Hydrogel‐forming microneedle (HFMN)‐reservoir patches provide a modular route for controlled transdermal delivery of hydrophilic biomacromolecules. The platform integrates skin‐barrier penetration, sustainable biopolymers, scalable green manufacturing, hydration‐driven transport, model‐cargo validation, and translational quality requirements.
Siddharth Mohanty, Mehmet Onur Aydogdu, Sijia Kang, Xinbo Li, Mohan Edirisinghe   +4 more
wiley   +1 more source

Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links

Advanced Science, EarlyView.
Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou, Keqing Wang, Junhong Chen, Haoyu Wang, Xinjiang Tan, Xuanlin Huang, Zhiyin Lin, Xun Xu, Xin Jin, Shaoqiao Zhang, Liang Xiao, Yuanqiang Zou, Tao Zhang, Xiaomin Liu   +13 more
wiley   +1 more source

Hydrogen Production from Ammonia Electrochemical Cracking

Advanced Science, EarlyView.
NH3 electrochemical cracking (e‐cracking) is a complementary technique to centralized thermal cracking for releasing H2 from NH3. In this article, we review recent advances in catalyst development for these cracking techniques and conduct a techno‐economic analysis (TEA) to evaluate the economic feasibility of e‐cracking.
Yike Ye, Yi Shun Lim, Qian Wu, Kamal Elouarzaki, Zhichuan J. Xu   +4 more
wiley   +1 more source

Unlocking the Full Potential of Jumping Condensation on Microstructured Surfaces

Advanced Science, EarlyView.
Microcone arrays exhibit a spacing‐dependent transition between jumping and non‐jumping condensation. Dense microstructures favor full Cassie droplets, which depart cleanly, while wider spacing favors partial Cassie droplets that retain a localized wet region initiating new nucleation. These findings establish a link between microdroplet morphology and
Mariia S. Kiseleva, Tytti Kärki, Mika Latikka, Parham Koochak, Sakari Lepikko, Maja Vuckovac, Tomi Koskinen, Ramesh Raju, Ville P. Jokinen, Jiazheng Liu, Nenad Miljkovic, Jaakko V. I. Timonen, Ilkka Tittonen, Robin H. A. Ras   +13 more
wiley   +1 more source

Interface Rectification via Roll‐to‐Roll Dual‐Confinement Nanocoatings for High‐Temperature Polymer Capacitors

Advanced Science, EarlyView.
Dual confinement in self‐assembled nanocoatings regulates polymer dynamics and hot‐carrier transport, enabling an interface‐rectification strategy for high‐temperature polymer capacitive energy storage. ABSTRACT Polymer film capacitors are indispensable for energy storage and power conversion, yet their energy density and efficiency deteriorate rapidly
Ning Guo, Marina Dabaghian, Jierui Zhou, Josh N. Bodin, Chong Xiang, Fei Wang, Antigoni Konstantinou, Dingxin Wei, Yifei Wang, Chao Wu, Riccardo Casalini, Bryan Huey, Priya Vashishta, Luyi Sun, Yang Cao   +14 more
wiley   +1 more source

Prepolymerization Enables On‐Demand Viscosity Tuning for Xolography of Soft Hydrogels

Advanced Science, EarlyView.
A facile in situ prepolymerization strategy enables on‐demand viscosity tuning across three orders of magnitude without external thickeners, transforming low‐viscosity resins into printable formulations for Xolography. The approach suppresses sedimentation, lowers curing dose, enables high‐fidelity support‐free fabrication, and produces advanced ...
Xichuan Li, Marcus Reuter, Linguangze Zhuo, Xueheng Dai, Camille Tribout, Nathaniel Corrigan, Jin Zhang, Cyrille Boyer   +7 more
wiley   +1 more source

Habitat‐Specific Design Strategies for Untethered Soft Robots

Advanced Science, EarlyView.
Habitat shapes the design of untethered soft robots. Across land, water, air, and living tissues, environmental constraints govern viable combinations of compliant structures, actuation mechanisms, and energy delivery. This review connects these constraints with robotic performance and identifies design principles for advancing adaptable, durable, and ...
Siyang Li, Zhikun Miao, Tuck‐Whye Wong, Tiefeng Li   +3 more
wiley   +1 more source

Melatonin Mitigates Doxorubicin‐Induced Cardiotoxicity by Targeting the USP18/PKM2 Axis Without Compromising Antitumor Efficacy

Advanced Science, EarlyView.
Melatonin engages MT1/MT2 receptors to suppress STAT1‐driven USP18 upregulation, thereby redirecting PKM2 ubiquitination from K33‐linked autophagic degradation toward K27‐linked nuclear translocation. This prevents PKM2‐mediated proinflammatory gene expression in the heart, alleviating doxorubicin‐induced cardiotoxicity without compromising antitumor ...
Zhenyu Feng, Yijin Yang, Jie Bai, Pengqi Sun, Xuyang Sun, Jinshu Shang, Yang Liu, Zhen Ning, Ningning Zhang, Yun‐long Xia, Yunpeng Xie   +10 more
wiley   +1 more source

Zr Incorporation Into Lithium Nickel Oxides: Bulk or Surface Substitution?

Advanced Science, EarlyView.
Mechanism of Zr incorporation into lithium nickel oxide (LNO) cathodes is studied from atomistic to macroscale. Zr doping enhances cyclability of Li‐ion batteries with LNO via bulk, interface, and grain boundary optimization leading to structural integrity at atomistic‐ and micro‐scale of secondary particle aggregates.
Lars Winkler, Geon‐Tae Park, Liang‐Yin Kuo, Martin Ihrig, Konstantin Köster, Johan E. ten Elshof, Mark Huijben, Myoung‐Chan Kim, Min‐Gyu Seo, Yang‐Kook Sun, Payam Kaghazchi   +10 more
wiley   +1 more source