Effect of hypergravity on the biomechanics of the musculoskeletal system in human lumbar spine: a numerical study [PDF]
Frontiers in Bioengineering and BiotechnologyThe aim of this study was to investigate the effects of hypergravity on the biomechanics of the human lumbar spinal musculoskeletal system. We quantitatively analyzed the biomechanics of the intervertebral disc (IVD), lumbar spinal muscles, and ligament ...
Bing Qin +5 more
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Hypergravity reduces F-actin accumulation in osteoclasts, with attenuated bone resorption. [PDF]
PLoS ONEBone loss occurs in astronauts during prolonged spaceflight, thus indicating the sensitivity of skeletal homeostasis to altered gravitational environments.
Natsuhiro Takahashi +6 more
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Modulation of vestibular function and receptor expression by experimental hypergravity in a rat model [PDF]
Scientific ReportsMotion sickness develops because of a mismatch or conflict between the information gathered from the visual input, somatosensory input, and the vestibular system. Altered gravity can cause motion sickness while traveling in space. In this study, we aimed
Jin Sil Choi +4 more
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Effects of altered gravity on adrenergic-mediated cAMP signalling in intact cells [PDF]
npj MicrogravitySpaceflight-induced cardiac atrophy and rhythm disorders are linked to dysregulation of the adrenergic-cAMP-PKA pathway. Gravity-dependent alterations in adrenergic signaling, particularly cAMP dynamics, remain poorly understood.
Marc Bathe-Peters +9 more
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Hypergravity is more challenging than microgravity for the human sensorimotor system [PDF]
npj MicrogravityThe importance of gravity for human motor control is well established, but it remains unclear how the central nervous system accounts for gravitational changes to perform complex motor skills.
Loïc Chomienne +3 more
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Biomedical response of femurs in male Wistar rat in chronic hypergravity environments
Medicine in Novel Technology and Devices, 2022 Bone is sensitive to mechanical stimulation and plays a loading-bearing role in the human body. However, regulation of bone biomechanical properties in chronic hypergravity environments is still unclear. In this study, male Wistar rats exposed to chronic
Lu Yu +5 more
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Hypergravity enhances the therapeutic effect of dexamethasone in allergic asthma and rhinitis animal model. [PDF]
PLoS ONE, 2018 We investigated whether the therapeutic effects of dexamethasone for allergic asthma and rhinitis were enhanced in mice when exposed to hypergravity. Forty mice were divided into 5 groups (n = 8/group): Control group received saline intraperitoneally (i ...
Tae Young Jang +3 more
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Scientific Reports, 2021 Hypergravity—an evolutionarily novel environment has been exploited to comprehend the response of living organisms including plants in the context of extra-terrestrial applications.
Basavalingayya K. Swamy +5 more
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Effects of Hypergravity on Osteopontin Expression in Osteoblasts. [PDF]
PLoS ONE, 2015 Mechanical stimuli play crucial roles in bone remodeling and resorption. Osteopontin (OPN), a marker for osteoblasts, is important in cell communication and matrix mineralization, and is known to function during mechanotransduction.
Shuai Zhou +4 more
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Yantu gongcheng xuebao, 2022 To study the temperature transfer laws of the air clearance space of the geotechnical model box in the hyper gravity field for design of the hyper gravity test platform tests in cold regions, the convection heat transfer model for clearance soil is ...
CHEN Hong-yong 1, 2, ZHANG Chen 3, LI Qi-sheng 1, WANG Dong 1, 2, SHEN Zhan-peng 1, 2, FANG Ye 1, 2, HE Qin-shu 1, 2
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