Impact of simulated microgravity in short-term evolution of an RNA bacteriophage [PDF]
Frontiers in MicrobiologyIntroductionMicrogravity is a critical environmental factor in space that can alter microbial physiology and virus–host interactions. Understanding these effects is essential for planetary protection and crew health during long-term missions ...
Alicia Rodríguez-Moreno +5 more
doaj +2 more sources
The mechanosensitive channel ELKIN1 regulates cellular adaptations to simulated microgravity [PDF]
npj MicrogravityIn conditions of microgravity the human body undergoes extensive alterations in physiological function. However, it has proven challenging to determine how these changes are mediated at the molecular and cellular level.
Daphne Wang +5 more
doaj +2 more sources
Integrated transcriptomic and proteomic analyses identify the TLR2–CXCR4 axis as a regulator of endothelial cell migration under simulated microgravity [PDF]
Frontiers in PhysiologySimulated microgravity profoundly alters endothelial function, particularly cell migration. However, the mechanosensitive molecular pathways involved remain incompletely understood.
Xiaodong Qin +5 more
doaj +2 more sources
The Growth of Soybean (Glycine max) Under Salt Stress Is Modulated in Simulated Microgravity Conditions [PDF]
CellsThe role of a simulated microgravity environment on soybean growth was investigated. The root grew more under simulated microgravity conditions than in the presence of gravity.
Setsuko Komatsu +6 more
doaj +2 more sources
Simulated Microgravity Causes Delayed Platelet Activation and Downregulates Acid-Sensing Ion Channel 1/2 Protein Expression [PDF]
BiomedicinesBackground: Microgravity is a physical force that affects cellular functions, including gene expression, cellular differentiation, proliferation, and signal transduction. Ion channels play an important role in ionic permeability and cell physiology.
Niharika Bala +4 more
doaj +2 more sources
CeO2 nanomaterial regulates wheat endophytic and rhizospheric bacteria to enhance resistance under simulated microgravity stress [PDF]
npj MicrogravityCertain nanomaterials, including cerium dioxide nanoparticle (CeO2 NP), have shown potential in modulating plant microbial communities to alleviate stressors like simulated microgravity.
Dengbo Chen +7 more
doaj +2 more sources
Simulated microgravity compromises mouse oocyte maturation by disrupting meiotic spindle organization and inducing cytoplasmic blebbing. [PDF]
PLoS ONE, 2011 In the present study, we discovered that mouse oocyte maturation was inhibited by simulated microgravity via disturbing spindle organization. We cultured mouse oocytes under microgravity condition simulated by NASA's rotary cell culture system, examined ...
Changli Wu +7 more
doaj +1 more source
Scientific Reports, 2021 Long non-coding RNAs (lncRNAs) are important in regulating the response to environmental stresses in organisms. In this study, we used Caenorhabditis elegans as an animal model to determine the functions of intestinal lncRNAs in regulating response to ...
Lingmei Sun +3 more
doaj +1 more source
VDR regulates simulated microgravity-induced atrophy in C2C12 myotubes
Scientific Reports, 2022 Muscle wasting is a major problem leading to reduced quality of life and higher risks of mortality and various diseases. Muscle atrophy is caused by multiple conditions in which protein degradation exceeds its synthesis, including disuse, malnutrition ...
Ryo Yuzawa +3 more
doaj +1 more source
Nanomaterials, 2022 With the increasing application of nanomaterials in aerospace technology, the long-term space exposure to nanomaterials especially in the space full of radiation coupled with microgravity condition has aroused great health concerns of the astronauts ...
Mei Wang +8 more
doaj +1 more source