Results 31 to 40 of about 17,651 (246)

Studies in microgravity, simulated microgravity and gravity do not support a gravitostat [PDF]

Journal of Endocrinology, 2020
The gravitostat is purported to function as a leptin-independent, osteocyte-dependent mechanism for regulation of energy balance. If correct, reduced activation of gravitostat signaling caused by prolonged sitting may contribute to obesity. The gravitostat concept is supported by reduced body mass in rodents following surgical implantation of weighted ...
Russell T, Turner, Adam J, Branscum, Carmen P, Wong, Urszula T, Iwaniec, Emily, Morey-Holton   +4 more
openaire   +2 more sources

Effects of Spaceflight on Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Structure and Function. [PDF]

, 2019
With extended stays aboard the International Space Station (ISS) becoming commonplace, there is a need to better understand the effects of microgravity on cardiac function. We utilized human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
Agrawal, Azakie, Baio, Becker, Bergmann, Burridge, Camberos, Connor, Drosatos, Fermini, Fritsch-Yelle, Garrett-Bakelman, Gauthier, Huebsch, Hughson, Jha, Kim, Kwon, Oikonomopoulos, Perhonen, Rogers, Sharma, Sharma, Sharma, Sides, Spotnitz, Sun, Thomason, Wnorowski, Wu, Yu   +30 more
core   +1 more source

Simulated Microgravity Promotes Angiogenesis through RhoA-Dependent Rearrangement of the Actin Cytoskeleton

Cellular Physiology and Biochemistry, 2017
Background/aims: Microgravity leads to hydrodynamic alterations in the cardiovascular system and is associated with increased angiogenesis, an important aspect of endothelial cell behavior to initiate new vessel growth.
Fei Shi, Yong-Chun Wang, Ze-Bing Hu, Hong-Yu Xu, Jing Sun, Yuan Gao, Xiao-tao Li, Chang-Bin Yang, Chao Xie, Cheng-Fei Li, Shu Zhang, Jiang-Dong Zhao, Xin-Sheng Cao, Xi-Qing Sun   +13 more
doaj   +1 more source

Simulated microgravity promotes the formation of tridimensional cultures and stimulates pluripotency and a glycolytic metabolism in human hepatic and biliary tree stem/progenitor cells [PDF]

, 2019
Many pivotal biological cell processes are affected by gravity. The aim of our study was to evaluate biological and functional effects, differentiation potential and exo-metabolome profile of simulated microgravity (SMG) on human hepatic cell line (HepG2)
Alvaro, Domenico, Berloco, Pasquale Bartolomeo, Bizzarri, Mariano, Cardinale, Vincenzo, Carpino, Guido, Casadei, Luca, Costantini, Daniele, Di Matteo, Sabina, Gaudio, Eugenio, Manetti, Cesare, Melandro, Fabio, Nevi, Lorenzo, Overi, Diletta, Safarikia, Samira, Valerio, Mariacristina   +14 more
core   +2 more sources

Simulated Microgravity Modulates Differentiation Processes of Embryonic Stem Cells

Cellular Physiology and Biochemistry, 2016
Background/Aims: Embryonic developmental studies under microgravity conditions in space are very limited. To study the effects of altered gravity on the embryonic development processes we established an in vitro methodology allowing differentiation of ...
Vaibhav Shinde, Sonja Brungs, Margit Henry, Lucia Wegener, Harshal Nemade, Tamara Rotshteyn, Aviseka Acharya, Christa Baumstark-Khan, Christine E. Hellweg, Jürgen Hescheler, Ruth Hemmersbach, Agapios Sachinidis   +11 more
doaj   +1 more source

PINK1-Dependent Mitophagy Reduced Endothelial Hyperpermeability and Cell Migration Capacity Under Simulated Microgravity

Frontiers in Cell and Developmental Biology, 2022
The effect of cardiovascular dysfunction including orthostatic intolerance and disability on physical exercise is one of the health problems induced by long-term spaceflight astronauts face.
Chengfei Li, Yikai Pan, Yingjun Tan, Yongchun Wang, Xiqing Sun   +4 more
doaj   +1 more source

An assessment of the long-term effects of simulated microgravity on cranial neural crest cells in zebrafish embryos with a focus on the adult skeleton.

PLoS ONE, 2014
It is becoming increasingly important to address the long-term effects of exposure to simulated microgravity as the potential for space tourism and life in space become prominent topics amongst the World's governments. There are several studies examining
Sara C Edsall, Tamara A Franz-Odendaal
doaj   +1 more source

Effect of Simulated Microgravity on the Activity of Regulatory Enzymes of Glycolysis and Gluconeogenesis in Mice Liver [PDF]

, 2014
Gravity supports all the life activities present on earth. Microgravity environments have effect on the biological functions and physiological status of an individual.
Adaikkappan Periyakaruppan, ., Chidananda Sharma, S., Govindarajan T Ramesh, ., Joaquin Ramirez, ., Shubhashish Sarkar, .   +4 more
core   +1 more source

The adaptation of Escherichia coli cells grown in simulated microgravity for an extended period is both phenotypic and genomic

npj Microgravity, 2017
Evolution: Bacteria gain advantageous mutations under simulated microgravity Bacteria grown for an extended period of time under simulated microgravity adopt growth advantages.
Madhan R. Tirumalai, Fathi Karouia, Quyen Tran, Victor G. Stepanov, Rebekah J. Bruce, C. Mark Ott, Duane L. Pierson, George E. Fox   +7 more
doaj   +1 more source

Simulated Microgravity-Induced Changes to Drug Response in Cancer Cells Quantified Using Fluorescence Morphometry

Life, 2023
Unlike plants that have special gravity-sensing cells, such special cells in animals are yet to be discovered. However, microgravity, the condition of apparent weightlessness, causes bone, muscular and immune system dysfunctions in astronauts following ...
Spencer McKinley, Adam Taylor, Conner Peeples, Megha Jacob, Gargee Khaparde, Yohan Walter, Andrew Ekpenyong   +6 more
doaj   +1 more source