Results 21 to 30 of about 4,453 (185)

WWP1 Deficiency Alleviates Cardiac Remodeling Induced by Simulated Microgravity

open access: yesFrontiers in Cell and Developmental Biology, 2021
Cardiac muscle is extremely sensitive to changes in loading conditions; the microgravity during space flight can cause cardiac remodeling and function decline.
Guohui Zhong   +12 more
doaj   +1 more source

Hydrogels in Simulated Microgravity: Thermodynamics at Play. [PDF]

open access: yesGels
Hydrogels have become indispensable in biomedical research and regenerative therapies due to their high water content, tissue-like mechanics, and tunable biochemical properties. However, their behavior under altered gravitational conditions—particularly simulated microgravity (SMG)—presents a frontier of challenges and opportunities that remain ...
Sepahvandi A   +4 more
europepmc   +4 more sources

Experimental study on effect of simulated microgravity on structural chromosome instability of human peripheral blood lymphocytes. [PDF]

open access: yesPLoS ONE, 2014
Experimental study was made by keeping human peripheral blood lymphocytes under simulated microgravity in a Rotary Cell Culture System bioreactor to investigate the changes that occur in the number of chromosomes, the expression rate of chromosome ...
Lijun Wei   +6 more
doaj   +1 more source

Centrifuges for Microgravity Simulation. The Reduced Gravity Paradigm [PDF]

open access: yesFrontiers in Astronomy and Space Sciences, 2016
Due to the cumbersome nature of performing real microgravity - spaceflight research scientists have been searching for alternatives to perform simulated microgravity or partial gravity experiments on Earth. For more than a century one uses the slow rotating clinostat as developed by von Sachs at the end of the nineteenth century.
Jack J.W.A. van Loon   +1 more
openaire   +7 more sources

Effect of Simulated Microgravity Condition on Cells Proliferation and Myostatin Gene Expression in Differentiated Skeletal Muscle Cells (C2C12) [PDF]

open access: yesفصلنامه علوم و فناوری فضایی, 2022
Muscle atrophy is one of the problems that astronauts face after returning to earth. Myostatin is a known negative regulator of muscle growth. This study aimed to investigate the effects of simulated microgravity condition on mouse myotube cells (C2C12 ...
Narjes Rahmanian   +2 more
doaj   +1 more source

Characterization of Human Chondrocytes Exposed to Simulated Microgravity [PDF]

open access: yesCellular Physiology and Biochemistry, 2010
Tissue engineering is a strategy of cartilage regeneration, but scaffolds, required for 3D growth of chondrocytes, are still a problem.Searching for possibilities to improve scaffold-free engineering of cartilage, we characterized human chondrocytes incubated on a random positioning machine (RPM) to simulate microgravity (microg).When cultured in ...
Ulbrich, Claudia   +11 more
openaire   +2 more sources

Simulated Microgravity-Induced Changes to Drug Response in Cancer Cells Quantified Using Fluorescence Morphometry

open access: yesLife, 2023
Unlike plants that have special gravity-sensing cells, such special cells in animals are yet to be discovered. However, microgravity, the condition of apparent weightlessness, causes bone, muscular and immune system dysfunctions in astronauts following ...
Spencer McKinley   +6 more
doaj   +1 more source

The adaptation of Escherichia coli cells grown in simulated microgravity for an extended period is both phenotypic and genomic

open access: yesnpj Microgravity, 2017
Evolution: Bacteria gain advantageous mutations under simulated microgravity Bacteria grown for an extended period of time under simulated microgravity adopt growth advantages.
Madhan R. Tirumalai   +7 more
doaj   +1 more source

Simulated Microgravity Exerts an Age-Dependent Effect on the Differentiation of Cardiovascular Progenitors Isolated from the Human Heart. [PDF]

open access: yesPLoS ONE, 2015
Microgravity has a profound effect on cardiovascular function, however, little is known about the impact of microgravity on progenitors that reside within the heart.
Tania I Fuentes   +6 more
doaj   +1 more source

Simulated Microgravity Promotes Angiogenesis through RhoA-Dependent Rearrangement of the Actin Cytoskeleton

open access: yesCellular Physiology and Biochemistry, 2017
Background/aims: Microgravity leads to hydrodynamic alterations in the cardiovascular system and is associated with increased angiogenesis, an important aspect of endothelial cell behavior to initiate new vessel growth.
Fei Shi   +13 more
doaj   +1 more source

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