Effects of Gravity, Microgravity or Microgravity Simulation on Early Mammalian Development [PDF]
Stem Cells and Development, 2018 Plant and animal life forms evolved mechanisms for sensing and responding to gravity on Earth where homeostatic needs require responses. The lack of gravity, such as in the International Space Station (ISS), causes acute, intra-generational changes in the quality of life.
Douglas M, Ruden +6 more
openaire +2 more sources
WWP1 Deficiency Alleviates Cardiac Remodeling Induced by Simulated Microgravity
Frontiers in Cell and Developmental Biology, 2021 Cardiac muscle is extremely sensitive to changes in loading conditions; the microgravity during space flight can cause cardiac remodeling and function decline.
Guohui Zhong +12 more
doaj +1 more source
Chronic exposure to simulated space conditions predominantly affects cytoskeleton remodeling and oxidative stress response in mouse fetal fibroblasts [PDF]
, 2014 Microgravity and cosmic rays as found in space are difficult to recreate on earth. However, ground-based models exist to simulate space flight experiments.
Abou-El-Ardat, Khalil +11 more
core +2 more sources
Simulated microgravity in the ring-sheared drop [PDF]
npj Microgravity, 2020 AbstractThe ring-sheared drop is a module for the International Space Station to study sheared fluid interfaces and their influence on amyloid fibril formation. A 2.54-cm diameter drop is constrained by a stationary sharp-edged ring at some latitude and sheared by the rotation of another ring in the other hemisphere.
Patrick M. McMackin +7 more
openaire +2 more sources
Interplay of space radiation and microgravity in DNA damage and DNA damage response [PDF]
, 2017 In space, multiple unique environmental factors, particularly microgravity and space radiation, pose constant threat to the DNA integrity of living organisms.
Lu, Tao +4 more
core +2 more sources
Simulated Microgravity Using a Rotary Culture System Compromises the In Vitro Development of Mouse Preantral Follicles. [PDF]
PLoS ONE, 2016 Growing cells in simulated weightlessness condition might be a highly promising new technique to maintain or generate tissue constructs in a scaffold-free manner.
Shen Zhang +7 more
doaj +1 more source
Simulated microgravity-induced aortic remodeling
Journal of Applied Physiology, 2009 We have previously shown that microgravity and simulated microgravity induce an increase in human and rat aortic stiffness. We attempted to elucidate the mechanism(s) responsible for this increase in stiffness. We hypothesize that an alteration in vessel wall collagen or elastin content or in extracellular matrix (ECM) cross-linking either individually
Eric C, Tuday +3 more
openaire +3 more sources
Simulated Microgravity Induces Microvolt T Wave Alternans [PDF]
Annals of Noninvasive Electrocardiology, 2005 Background: There are numerous anecdotal reports of ventricular arrhythmias during spaceflight; however, it is not known whether spaceflight or microgravity systematically increases the risk of cardiac dysrhythmias. Microvolt T wave alternans (MTWA) testing compares favorably with other noninvasive risk stratifiers and invasive electrophysiological ...
S Marlene, Grenon +7 more
openaire +2 more sources
Expression pattern of neurotrophins and their receptors during neuronal differentiation of adipose-derived stem cells in simulated microgravity condition [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Objective(s): Studies have confirmed that microgravity, as a mechanical factor, influences both differentiation and function of mesenchymal stem cells. Here we investigated the effects of simulated microgravity on neural differentiation of human adipose ...
Vajiheh Zarrinpour +2 more
doaj +1 more source
Adaptation to simulated microgravity in Streptococcus mutans
npj Microgravity, 2022 AbstractLong-term space missions have shown an increased incidence of oral disease in astronauts’ and as a result, are one of the top conditions predicted to impact future missions. Here we set out to evaluate the adaptive response of Streptococcus mutans (etiological agent of dental caries) to simulated microgravity.
Mizpha C. Fernander +5 more
openaire +3 more sources