Results 51 to 60 of about 166,212,796 (263)

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Screening the human mind: A Deleuzian approach to altered states of consciousness in cinema history

open access: yesAN-ICON, 2022
From its very origins, cinema has demonstrated a particular interest in the representation of altered states of consciousness: memories, visions, nightmares and dreams are a common feature of narrative films and usually interrupt a flow of events by ...
Federica Cavaletti
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Concepts of ecstasy in Euripides’ “Bacchanals” and their interpretation

open access: yesScripta Instituti Donneriani Aboensis, 1982
In dealing with ecstasy in antiquity, scholars usually refer to Euripides'  "Bacchanals"' as one of the most reliable sources with regard to this phenomenon. This drama can also be supplemented by vase paintings, which to a great extent deal with motives
Lilian Portefaix
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Psychoactive Drugs and Alterations to Consciousness

open access: yes, 2009
Altered states of consciousness (ASC) are difficult to define and previous attempts to do so have not been widely adopted. This is a problem inherent in defining consciousness in general. Theories that link ASC to neural substrates, such as the transient
Dietrich A., A. Dietrich
core   +1 more source

Spirit-possession in theory and practice: séances with Tibetan spirit-mediums in Nepal

open access: yesScripta Instituti Donneriani Aboensis, 1982
This paper describes a short study of the séances and trance-performances of three Tibetan spirit-mediums (dpa' bo) from a refugee-community in Nepal.
Per-Arne Berglie
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Consciousness: A Neurological Perspective

open access: yesBehavioural Neurology, 2011
Consciousness is a state so essentially entwined with human experience, yet so difficult to conceptually define and measure. In this article, we explore how a bidimensional model of consciousness involving both level of arousal and subjective awareness ...
Andrea E. Cavanna   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

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