Results 61 to 70 of about 166,212,796 (263)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
The transient hypofrontality theory of altered states of consciousness
, 2018 Consciousness-altering behaviour is, to a first approximation, a universal phenomenon; practically all human societies have experimented with altered states of consciousness (ASCs) in some form.
Dietrich, Arne, Al-Shawaf, Laith
core
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
A Consensus Taxonomy of Altered (Nonordinary) States of Consciousness: : Bringing Order to Disarray
This article presents a taxonomy of altered states of consciousness, primarily based on their central phenomenological features. Following taxonomic principles and a modified Delphi methodology, a multidisciplinary, international group identified eight ...
Luhrmann, Tanya +17 more
core +1 more source
Eastern Approaches to Altered States of Consciousness [PDF]
, 2011 Eastern civilizations have traditionally placed much greater emphasis on altered states of consciousness than the civilizations of the West. Altered, higher states are crucial to the major Eastern religions.
Shear, Jonathan
core
Aging and Cancer, EarlyView.Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi +3 more
wiley +1 more source
Mental unity, altered states of consciousness and dissociation
, 1990 p. 154-159This model for understanding altered states of consciousness and dissociation is based on the hypothesis that normal consciousness depends on an illusion of mental unity generated by certain dynamic brain processes.
Tinnin, Louis
core +1 more source
The nose and altered states of consciousness: Tascodrugites and Ezekiel
HTS Teologiese Studies/Theological Studies, 2002 The Church Father Epiphanius' description of the Tascodrugite practice of placing the forefinger on the nostril during prayer call be plausibly interpreted as a strategy for inducing an altered state of consciousness (ASC).
John J. Pilch
doaj +1 more source