Results 51 to 60 of about 703,394 (261)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Simulation of reactivity-initiated accident transients on UO2-M5® fuel rods with ALCYONE V1.4 fuel performance code

Nuclear Engineering and Technology, 2018
The ALCYONE multidimensional fuel performance code codeveloped by the CEA, EDF, and AREVA NP within the PLEIADES software environment models the behavior of fuel rods during irradiation in commercial pressurized water reactors (PWRs), power ramps in ...
Isabelle Guénot-Delahaie, Jérôme Sercombe, Thomas Helfer, Patrick Goldbronn, Éric Fédérici, Thomas Le Jolu, Aurore Parrot, Christine Delafoy, Christian Bernaudat   +8 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Synthesis of titanium (IV) oxide composite membrane for hydrogen production through alkaline water electrolysis

South African Journal of Chemical Engineering, 2018
Alkaline water electrolysis is one of the most efficient methods for the hydrogen production. In this method widely used as the asbestos membrane as a separator, but this material is hazardous for health, causing cancer, in order to limit the usage of an
S. Shiva Kumar, S.U.B. Ramakrishna, S. Vijaya Krishna, K. Srilatha, B. Rama Devi, V. Himabindu   +5 more
doaj   +1 more source

Alternative Energy: Future Energy

Journal of Industrial Technology and Innovation, 2022
พลังงาน เป็นความสามารถในการทำงานหรือทำให้เกิดงาน ผลการทำงานของแรงนั้นทำให้วัตถุหรือสิ่งใด ๆ เคลื่อนที่ หรือเคลื่อนไหว พลังงานนั้นสามารถจัดเก็บไว้ได้พลังงานไม่สามารถถูกทำลายได้ แต่สามารถเปลี่ยนแปลงจากรูปหนึ่งไปเป็นอีกรูปหนึ่งได้  เช่น พลังงานจลน์ พลังงานศักย์พลังงานกล พลังงานไฟฟ้า พลังงานความร้อน พลังงานชีวะ พลังงานน้ำ พลังงานความร้อนใต้พิภพ พลังงานลม ...
openaire   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A Techno-Economic Study of 100% Renewable Energy for a Residential Household in China

Energies, 2019
In the context of global warming and energy shortage, this paper discusses the techno-economic feasibility of a residential household based on 100% renewable energy in China.
Zhe Lv, Zengping Wang, Wanyu Xu
doaj   +1 more source