Results 31 to 40 of about 104,490 (216)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Barataria, 2020 This essay aims to investigate the development of the organic agriculture movement and the evolution over time of its movement and consumer culture. The analysis is especially focused on the most recent evolution of the sector in the Italian context ...
Stefano Spillare
doaj +1 more source
Building Resilience in Nonprofit Food Hubs
Journal of Agriculture, Food Systems, and Community Development, 2016 Food hubs serve as intermediaries between market actors in the aggregation and distribution of local food. Scholars have identified four common food hub models: retail-driven, nonprofit-driven, producer-driven, and consumer-driven.
Jacqueline R. LeBlanc +3 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Journal of Agriculture, Food Systems, and Community Development, 2021 This article explores the potential of alternative food networks (AFNs) for food security and resilience as COVID-19 has raised challenges to the global food supply chain. Pandemic-induced disruptions to conventional food production, distribution, and
Nurcan Atalan-Helicke, Bürge Abiral
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Beyond Animal‐Based Diets? Alternative Food Networks and Vegetarianism in the City of Buenos Aires
Geo: Geography and EnvironmentThis article aims to advance on a little‐known topic, the relationship between participation in alternative food supply networks (AFN) and the vegetarian condition of consumers in the city of Buenos Aires.
Clara Craviotti
doaj +1 more source
Agriculture, 2017 Presently, alternative agri-food networks are in a renaissance, utilizing an economy of proximity to compete against transnational agri-business and food distributors.
Mario Del Roble Pensado-Leglise +1 more
doaj +1 more source