Results 91 to 100 of about 1,598,018 (302)
Evolution of virulence: triggering host inflammation allows invading pathogens to exclude competitors. [PDF]
, 2008 Virulence is generally considered to benefit parasites by enhancing resource-transfer from host to pathogen. Here, we offer an alternative framework where virulent immune-provoking behaviours and enhanced immune resistance are joint tactics of invading ...
Alizon S. +9 more
core +3 more sources
Multicolour Optical Imaging of IR-Warm Seyfert Galaxies. V. Morphologies and Interactions. Challenging the Orientation Model [PDF]
, 1999 This paper is the last in a series, investigating the optical properties of a sample of mid-IR Warm Seyfert galaxies and of a control sample of mid-IR cold galaxies.
Antonucci R. R. J. +20 more
core +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
The Heterogeneity of MNC' Subsidiaries and Technology Spillovers: Explaining positive and negative effects in emerging economies [PDF]
Conventional models of multinational corporation (MNC) related spillovers in host economies assume that they derive from the technological assets created at the headquarters.
Marin, Anabel, Sasidharan, Subash
core
On the Role of Dewetting Transitions in Host-Guest Binding Free Energy Calculations. [PDF]
, 2013 We use thermodynamic integration (TI) and explicit solvent molecular dynamics (MD) simulation to estimate the absolute free energy of host-guest binding.
Baron, Riccardo +5 more
core
Effects of Biases in Virial Mass Estimation on Cosmic Synchronization of Quasar Accretion
, 2011 Recent work using virial mass estimates and the quasar mass-luminosity plane has yielded several new puzzles regarding quasar accretion, including a sub-Eddington boundary on most quasar accretion, near-independence of the accretion rate from properties ...
Begelman +27 more
core +1 more source
Alternate Plant Hosts of Rice Leaffolder (LF)
, 1990 This article 'Alternate Plant Hosts of Rice Leaffolder (LF)' appeared in the International Rice Research Newsletter series, created by the International Rice Research Institute (IRRI). The primary objective of this publication was to expedite communication among scientists concerned with the development of improved technology for rice and for rice ...
Bharati, L. R., Om, H., Kushwaha, K. S.
openaire +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Frontiers in Plant ScienceBanana bunchy top disease is caused by banana bunchy top virus (BBTV). BBTV is transmitted locally by aphids (Pentalonia spp.), but the long-distance spread is through the movement of infected planting materials.
Nicole Angelee P. Mendoza +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source