Results 101 to 110 of about 9,412,461 (300)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Study of mechanical properties of multilayer composite plastic blocks with various materials

Journal of Asian Architecture and Building Engineering
Plastic waste is considered a global environmental disaster due to its extensive negative impacts on ecosystems, human health, and the overall well-being of the planet. Approximately 91% of plastic waste, including multi-layer plastic (MLP), is yet to be
Lily Tambunan, Chibhatul Mufrida, Dewi Larasati   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Alternative

, 2017
Unconventional, uncommon, irregular, off-beat, counter to as in contradistinction to the popular. Here we look to the margins of film and media, practice and industry to explore alternative approaches to popular modes of thinking and doing. The theme of ‘
Grady Hancock (13073166)
core  

Effects of the binder material on the mechanical properties of thick-film magnetostrictive materials

, 2004
This paper presents research carried out at the University of Southampton into the development of a magnetostrictive thick-film material suitable for use with silicon micromachined devices.
White, Neil M., Grabham, Neil J., Beeby, Steve P.   +2 more
core   +1 more source

Stuff happens: a material culture approach to textile conservation

, 2009
Textile conservation, defined here as the preservation, investigation andpresentation of textiles, is often viewed largely as a technical andaesthetic problem.
Eastop, Dinah
core   +1 more source

Bamboo as a sustainable alternative construction material: A review

Advances in Bamboo Science
Bamboo is one of the fastest-growing plants in the world, naturally abundant, and recognized as a highly sustainable and renewable material resource. Although the existing literature highlights its potential in the construction industry, bamboo's use ...
Wonder Salami Davor, Lucas Nana Wiredu Damoah, Benjamin Agyei-Tuffour   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Innovative approaches to sustainable construction: a detailed study of rice husk ash as an eco-friendly substitute in cement production

Discover Applied Sciences
An immense amount of rice is cultivated globally, leading to the generation of large amounts of rice husk. Unfortunately, this husk is often disposed of in natural settings and lagoons.
M. Indumathi, G Nakkeeran, Dipankar Roy, Sonu Kumar Gupta, George Uwadiegwu Alaneme   +4 more
doaj   +1 more source