Results 111 to 120 of about 9,412,461 (300)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Office of Innovative Partnerships Program

open access: yes, 2013
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF caption (viewed on April 1, 2014)Mode of ...

core  

The Oxford handbook of material culture studies

open access: yes, 2010
The Oxford Handbook of Material Culture Studies introduces and reviews current thinking in the interdisciplinary field of material culture studies. Drawing together approaches from archaeology, anthropology, geography, and Science and Technology Studies,

core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Alternative sewer systems

open access: yes, 2008
xxvi+308hlm ...
ALTERNATIVE
core  

Eco-friendly metakaolin-basalt geopolymer blocks: A sustainable building material alternative

open access: yesNext Sustainability
This study investigates the development and characterization of eco-friendly metakaolin-based geopolymer blocks incorporating basalt rock powder as a silica source.
Blasius Ngayakamo, Silke Christiansen
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Two-dimensional material-based memristive devices for alternative computing

open access: yesNano Convergence
Two-dimensional (2D) materials have emerged as promising building blocks for next generation memristive devices, owing to their unique electronic, mechanical, and thermal properties, resulting in effective switching mechanisms for charge transport ...
Jey Panisilvam   +4 more
doaj   +1 more source

Alternative gamma-ray shielding material: Ternary composite including polyester resin/barite/molybdenum

open access: yesNuclear Engineering and Technology
In the present study, ternary composites containing different proportions of barite and molybdenum and using unsaturated polyester resin as binder were produced.
H.Gurel Ozdemir   +3 more
doaj   +1 more source

Alternative material [PDF]

open access: yesBritish Dental Journal, 2008
openaire   +1 more source

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