Results 121 to 130 of about 17,755,012 (348)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

An Alternative Host Material for Long‐Lifespan Blue Organic Light‐Emitting Diodes Using Thermally Activated Delayed Fluorescence

Advancement of science, 2017
It has been challenging to find stable blue organic light emitting diodes (OLEDs) that rely on thermally activated delayed fluorescence (TADF). Lack of stable host materials well‐fitted to the TADF emitters is one of the critical reasons.
Soo‐Ghang Ihn, Namheon Lee, S. Jeon, M. Sim, Hosuk Kang, Yongsik Jung, Dal Ho Huh, Y. Son, S. Lee, Masaki Numata, H. Miyazaki, Rafael Gómez-Bombarelli, J. Aguilera-Iparraguirre, Timothy D. Hirzel, Alán Aspuru-Guzik, Sunghan Kim, Sangyoon Lee   +16 more
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Bacterial Nanocellulose Hydrogel: A Promising Alternative Material for the Fabrication of Engineered Vascular Grafts. [PDF]

Polymers (Basel), 2023
Liu D, Meng Q, Hu J.
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Two-dimensional material-based memristive devices for alternative computing

Nano Convergence
Two-dimensional (2D) materials have emerged as promising building blocks for next generation memristive devices, owing to their unique electronic, mechanical, and thermal properties, resulting in effective switching mechanisms for charge transport ...
Jey Panisilvam, Ha Young Lee, Sujeong Byun, Daniel Fan, Sejeong Kim   +4 more
doaj   +1 more source

An Alternative Material Model Using a Generalized J2 Finite-Strain Flow Plasticity Theory with Isotropic Hardening

International Journal of Applied Mechanics and Engineering, 2018
In this paper an alternative material model using a generalized J2 finite-strain flow plasticity theory with isotropic hardening is presented. The model is based on a new nonlinear continuum mechanical theory of finite deformations of elasto-plastic ...
L. Écsi, P. Élesztős
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Alternative gamma-ray shielding material: Ternary composite including polyester resin/barite/molybdenum

Nuclear Engineering and Technology
In the present study, ternary composites containing different proportions of barite and molybdenum and using unsaturated polyester resin as binder were produced.
H.Gurel Ozdemir, M.R. Kacal, F. Akman, H. Polat   +3 more
doaj   +1 more source

Optically switched magnetism in photovoltaic perovskite CH$_3$NH$_3$(Mn:Pb)I$_3$

, 2016
The demand for ever-increasing density of information storage and speed of manipulation boosts an intense search for new magnetic materials and novel ways of controlling the magnetic bit.
Arakcheeva, A., Chernyshov, D., Forró, L., Gibert, M., Horváth, E., Lee, H., Náfrádi, B., Spina, M., Szirmai, P., Yazyev, O. V.   +9 more
core   +4 more sources