Results 51 to 60 of about 1,235,798 (266)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
NICKEL AS AN ALTERNATIVE AUTOMOTIVE BODY MATERIAL [PDF]
Journal of Mechanical Engineering and Sciences, 2012 The study of the thermal, chemical and mechanical properties of pure nickel as an alternative automotive body material is presented in this paper. Current automotive components mainly use steel as the body material.
T. Joseph Sahaya Anand
doaj
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Review on Alternatives of Aggregates with Alternative Materials in Eastern Africa [PDF]
Selected Scientific Papers - Journal of Civil Engineering, 2020 Abstract Normal concrete, with bulky aggregate generally results to large amount of energy and natural resource requirement. Normal aggregates mining and river sand extraction, if done in unsustainably, potentially results in adverse environmental, health or hazardous impacts.
openaire +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Chemical Composition of Straw as an Alternative Material to Wood Raw Material in Fibre Isolation
Drvna Industrija, 2016 Wood is still the most widely used raw material for pulp and paper production in the world. However, due to the necessity to supply the paper industry with raw materials used in the extraction of cellulose fibres and the overexploitation of forests, new ...
Željka Barbarić-Mikočević +1 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Insects feeding on cadavers as an alternative source of human genetic material
Archives of Forensic Medicine and Criminology, 2015 In some criminal cases, the use of classical sources of human genetic material is difficult or even impossible. One solution may be the use of insects, especially blowfly larvae which feed on corpses.
Rafał Skowronek +3 more
doaj +1 more source