Results 51 to 60 of about 9,412,461 (300)
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Com o aumento da população nos últimos anos, a indústria de modo geral tem se adequado à demanda resultante. A indústria do processo de recauchutagem de pneus gera resíduos que em sua maioria têm sido descartados sem nenhum controle.
Cesar Fabiano Fioriti +2 more
doaj
To boost productivity in pig production, it is essential to improve the litter size per sow. However, achieving this goal requires reducing newborn mortality rates and increasing their weight gain. In this regard, prioritizing animal welfare and adopting
Beatriz de Oliveira Possagnolo +6 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Bioconcrete as an alternative sustainable construction material [PDF]
The overall aim of the present research project is to examine the feasibility of industrialising a disruptive, carbon negative bio-concrete technology (developed by Biozeroc).
Abbas Ali +7 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Seed fat from Madhuca longifolia as raw material for Halal alternative fats [PDF]
Lard extracted from swine is prohibited under halal and kosher food regulations. A study was carried out on Madhuca longifolia seed fat and lard to compare their solidification and melting characteristics to formulate halal alternative lipid substitutes.
Marikkar, Mohammed Nazrim
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source

