Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance
Advanced Science, EarlyView.Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer +9 more
wiley +1 more source
Potential of Berry Fruit Pomace for Application in Processed Meat as Natural Alternative to Nitrates and Nitrites. [PDF]
MoleculesSkwarek-Jóźwiak P, Karwowska M.
europepmc +1 more source
Advanced Science, EarlyView.Intrinsic phase toughening transforms a brittle B2 intermetallic into a plastically deformable, load‐bearing phase, while a heterogeneous laminated architecture suppresses strain localization and interface cracking. The synergy between ductile intermetallics and mesoscale heterogeneity establishes a general design strategy for breaking the long ...
Lu Yang +9 more
wiley +1 more source
Technological landscapes and sustainable transitions: reconfiguring the meat industry in Asia. [PDF]
Food Sci Anim ResourBassey AP, Zhang W, Zhou G.
europepmc +1 more source
Probing Electrocatalyst Design for Product Selectivity in CO2 Reduction
Advanced Science, EarlyView.Selective CO2 electroreduction is controlled by catalyst structure, dynamic surface reconstruction, adsorbate interactions, and reaction microenvironment. This review summarizes Cu‐ and non‐Cu‐based catalysts, single‐atom and molecular systems, degradation pathways, and operando/computational strategies for steering CO2RR toward hydrocarbons ...
Suvodeep Sen +5 more
wiley +1 more source
Recent Advances in Sustainable Yeast-Based Single-Cell Protein Production from Renewable Substrates Using Engineering Approaches. [PDF]
J Microbiol BiotechnolYosriah E +4 more
europepmc +1 more source
Advanced Science, EarlyView.Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng +19 more
wiley +1 more source
Advanced Science, EarlyView.Rigidity‐tunable nanovesicle (P‐Pm) with mechanically induced adjuvanticity toward tumor‐associated macrophages (TAMs) was designed to engineer R848/gp100 antigen ‐loaded nanovaccine (P@Rg‐Pm), which achieved outstanding anti‐tumor outcomes in both therapeutic and preventive model of B16‐F10 melanoma.
Bangyue Luo, Liyan Qiu
wiley +1 more source
Physiological and meat quality responses to phased and continuous hydrolyzed yeast (<i>Saccharomyces cerevisiae</i>) supplementation in densely stocked broiler chickens. [PDF]
Vet Anim SciMoreane N +7 more
europepmc +1 more source
Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States
Advanced Science, EarlyView.Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton +13 more
wiley +1 more source