Results 131 to 140 of about 5,418,796 (152)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Radiotheranostics in oncology: Making precision medicine possible

Ca-A Cancer Journal for Clinicians, 2023
Eric Aboagye
exaly  

Trends in Alternative Medicine Use in the United States, 1990-1997

JAMA - Journal of the American Medical Association, 1998
Roger Davis, Ronald Kessler, D M Eisenberg   +2 more
exaly  

Use of complementary and alternative medicine in cancer patients: a European survey

Annals of Oncology, 2005
Fernandez-Ortega P, Maria Brovall
exaly  

Why Patients Use Alternative Medicine

JAMA - Journal of the American Medical Association, 1998
John A Astin
exaly  

Physicians' Ethical Obligations Regarding Alternative Medicine

JAMA - Journal of the American Medical Association, 1998

exaly  

Investigating Alternative Medicine Therapies in Randomized Controlled Trials

JAMA - Journal of the American Medical Association, 1998
Arthur Margolin, Herbert D Kléber, S K Avants   +2 more
exaly  

Attitude of employees of a university clinic to complementary and alternative medicine in oncology

Annals of Oncology, 2013
J Huebner, S Wicker, O Micke
exaly