Results 1 to 10 of about 61,268 (292)

Induction of G2/M Cell Cycle Arrest and Apoptosis by Genistein in Human Bladder Cancer T24 Cells through Inhibition of the ROS-Dependent PI3k/Akt Signal Transduction Pathway

Antioxidants, 2019
We examined the anti-cancer effect of genistein, a soy-derived isoflavone, in human bladder transitional cell carcinoma T24 cells. According to our data, genistein induced G2/M phase arrest of the cell cycle and apoptosis.
Yung Hyun Choi, Cheol Park, Hee-Jae Cha
exaly   +3 more sources

Eudragit nanoparticles containing genistein: formulation, development, and bioavailability assessment

International Journal of Nanomedicine, 2011
Jingling Tang2, Na Xu1,2, Hongyu Ji1, Hongmei Liu1, Zhiyong Wang1, Linhua Wu1,2 1Department of Pharmacy, the Second Affiliated Hospital of Harbin Medical University, Key Laboratory of College in Heilongjiang Province; 2Department of Pharmaceutics, School
Tang J, Xu N, Ji H, Liu H, Wang Z, Wu L
doaj   +3 more sources

Genistein enhances anti-PD-1 efficacy in melanoma by suppressing regulatory T cell differentiation and activity [PDF]

Scientific Reports
The accumulation of regulatory T cells (Tregs) in the tumor microenvironment is a key factor for immunosuppression and immune escape of cancer cells.
Fei Mo, Min Hong, Xiao Chen, Qiye Wang, Chao Dong   +4 more
doaj   +2 more sources

Molecular Mechanisms of Action of Genistein in Cancer: Recent Advances

Frontiers in Pharmacology, 2019
Background: Genistein is one among the several other known isoflavones that is found in different soybeans and soy products. The chemical name of genistein is 4′,5,7-trihydroxyisoflavone.
Hardeep Singh Tuli, Katrin Sak, Manoj Kumar   +2 more
exaly   +3 more sources

Genistein treatment increases bone mass in obese, hyperglycemic mice

Diabetes, Metabolic Syndrome and Obesity, 2016
Richard M Michelin,1 Layla Al-Nakkash,2 Tom L Broderick,3 Jeffrey H Plochocki4 1Arizona College of Osteopathic Medicine, 2Department of Physiology, 3Laboratory of Diabetes and Exercise Metabolism, Department of Physiology, 4Department of Anatomy, Arizona
Michelin RM, Al-Nakkash L, Broderick TL, Plochocki JH   +3 more
doaj   +1 more source

Effects of genistein on glucose and lipid metabolism of common carp (Cyprinus carpio. L) in vivo and in vitro

Aquaculture Reports, 2022
Genistein exhibits anti-diabetic and anti-lipogenic effects in mammals, however, there are rare reports on the effects of genistein on glucose and lipid metabolism in fish.
Liping Yang, Wenlei Zhang, Shaoyang Zhi, Mingyu Liu, Mengjuan Zhao, Chaobin Qin, Xiao Yan, Junchang Feng, Guoxing Nie   +8 more
doaj   +1 more source

Co-treatment With Everolimus, an mTOR-Specific Antagonist, or Downregulation of ELK1 Enhances the Sensitivity of Pancreatic Cancer Cells to Genistein

Frontiers in Cell and Developmental Biology, 2021
Genistein is a natural isoflavone with pharmacological or potentially anti-tumor properties. However, the resistance of cancer cells to genistein remains a major obstacle.
Tianyu Li, Tiantao Kuang, Zhaoshuo Yang, Qiqi Zhang, Wen Zhang, Yue Fan, Yue Fan   +6 more
doaj   +1 more source

Genistein Inhibits Proliferation and Metastasis in Human Cervical Cancer Cells through the Focal Adhesion Kinase Signaling Pathway: A Network Pharmacology-Based In Vitro Study in HeLa Cells

Molecules, 2023
Previous studies have provided evidence that genistein exerts a therapeutic effect on different tumor cells. However, the mechanism of action of genistein against cervical cancer cells remains largely unknown. The aim of this study was to comprehensively
Tingting Chen, Juan Wang, Min Li, Qingqing Wu, Shuna Cui   +4 more
doaj   +1 more source

The Role of Genistein in Mammalian Reproduction

Molecules, 2023
Genistein is a natural compound belonging to flavonoids, having antioxidant, anti-inflammatory, and anti-neoplastic properties. Genistein is considered a phytoestrogen.
Gabriella Guelfi, Rolando Pasquariello, Polina Anipchenko, Camilla Capaccia, Georgia Pennarossa, Tiziana A. L. Brevini, Fulvio Gandolfi, Massimo Zerani, Margherita Maranesi   +8 more
doaj   +1 more source

Inhibition of castration-resistant prostate cancer growth by genistein through suppression of AKR1C3

Food & Nutrition Research, 2023
Background: Prostate cancer is the second leading cause of cancer-related death among males in America. The patients’ survival time is significantly reduced after prostate cancer develops into castration-resistant prostate cancer (CRPC).
Xiaoping Yu, Jiali Yan, Yulu Li, Jing Cheng, Lujie Zheng, Tianyu Fu, Yanfeng Zhu   +6 more
doaj   +1 more source