Results 11 to 20 of about 25,462 (209)

The Role of Genistein in Mammalian Reproduction

open access: yesMolecules, 2023
Genistein is a natural compound belonging to flavonoids, having antioxidant, anti-inflammatory, and anti-neoplastic properties. Genistein is considered a phytoestrogen.
Gabriella Guelfi   +8 more
doaj   +3 more sources

Genistein as a Potential Anticancer Agent against Ovarian Cancer

open access: yesJournal of Traditional and Complementary Medicine, 2012
Genistein is known as the major component of isoflavone, which is present in high-soy diets. Genistein has received much attention because of its chemopreventive and therapeutic effects on various types of cancers.
Jung-Yun Lee   +2 more
doaj   +3 more sources

Effects of genistein on glucose and lipid metabolism of common carp (Cyprinus carpio. L) in vivo and in vitro

open access: yesAquaculture Reports, 2022
Genistein exhibits anti-diabetic and anti-lipogenic effects in mammals, however, there are rare reports on the effects of genistein on glucose and lipid metabolism in fish.
Liping Yang   +8 more
doaj   +1 more source

Co-treatment With Everolimus, an mTOR-Specific Antagonist, or Downregulation of ELK1 Enhances the Sensitivity of Pancreatic Cancer Cells to Genistein

open access: yesFrontiers in Cell and Developmental Biology, 2021
Genistein is a natural isoflavone with pharmacological or potentially anti-tumor properties. However, the resistance of cancer cells to genistein remains a major obstacle.
Tianyu Li   +6 more
doaj   +1 more source

Genistein Inhibits Proliferation and Metastasis in Human Cervical Cancer Cells through the Focal Adhesion Kinase Signaling Pathway: A Network Pharmacology-Based In Vitro Study in HeLa Cells

open access: yesMolecules, 2023
Previous studies have provided evidence that genistein exerts a therapeutic effect on different tumor cells. However, the mechanism of action of genistein against cervical cancer cells remains largely unknown. The aim of this study was to comprehensively
Tingting Chen   +4 more
doaj   +1 more source

The obesogenic side of Genistein

open access: yesFrontiers in Endocrinology, 2023
Genistein (GN) has been highly recommended for its medicinal properties like anticancer, antidiabetic, antihyperlipidemic, antiviral, and antioxidant activities among others. Recently, scientists realized that Genistein is an endocrine disruptor. It is an obesogen that interferes with the endocrine system causing obesity through many mechanisms like ...
Jia Xiang   +14 more
openaire   +3 more sources

Genistein, a tool for geroscience

open access: yesMechanisms of Ageing and Development, 2022
Geroprotection is defined as protection from the adverse effects of aging. The need for geroprotection implies changes towards individually tailored interventions that preserve an individual's independence, physical function, and cognition. Genistein, a phytoestrogen obtained from soya, has been reported to have beneficial properties on age-related ...
Bargues C, Borras C, Vina J
openaire   +4 more sources

Inhibition of castration-resistant prostate cancer growth by genistein through suppression of AKR1C3

open access: yesFood & Nutrition Research, 2023
Background: Prostate cancer is the second leading cause of cancer-related death among males in America. The patients’ survival time is significantly reduced after prostate cancer develops into castration-resistant prostate cancer (CRPC).
Xiaoping Yu   +6 more
doaj   +1 more source

Nutrikinetic study of genistein metabolites in ovariectomized mice. [PDF]

open access: yesPLoS ONE, 2017
This study was designed to evaluate the effect of ovariectomy on nutrikinetics of genistein metabolites. To characterize the time-dependent changes in genistein metabolite concentrations, we identified 13 genistein metabolites using ultra-performance ...
Da-Hye Lee   +8 more
doaj   +1 more source

Genistein protects against hyperglycemia and fatty liver disease in diet-induced prediabetes mice via activating hepatic insulin signaling pathway

open access: yesFrontiers in Nutrition, 2022
IntroductionInsulin signaling via the insulin receptor (IR) may be associated with the amelioration of diet-induced metabolic syndrome. Genistein, a soy isoflavone, has been suggested to play a role in the amelioration of high-fat diet-induced metabolic ...
Nana Zhang   +6 more
doaj   +1 more source

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