Results 31 to 40 of about 25,462 (209)

Genistein prevents bone loss in type 2 diabetic rats induced by streptozotocin

Food & Nutrition Research, 2020
Background: Diabetic osteoporosis has become a severe public health problem in the aging societies. Genistein has been reported to play an important role in preventing and treating metabolic diseases via its anti-inflammatory, antioxidant, anti ...
Rongrong Lu, Zicong Zheng, Yimin Yin, Zhuoqin Jiang   +3 more
doaj   +1 more source

Activation of Chloride Secretion by Isoflavone Genistein in Endometrial Epithelial Cells

Cellular Physiology and Biochemistry, 2013
Background /Aim: Genistein, the most active isoflavone found primarily in soybeans, alters ion transport functions in intestinal and airway epithelia.
Chatsri Deachapunya, Sutthasinee Poonyachoti   +1 more
doaj   +1 more source

Biological evaluation of isoflavonoids from Genista halacsyi using estrogen-target cells: Activities of glucosides compared to aglycones.

PLoS ONE, 2019
The purpose of this study was to evaluate the response of estrogen target cells to a series of isoflavone glucosides and aglycones from Genista halacsyi Heldr.
Nikolas Fokialakis, Xanthippi Alexi, Nektarios Aligiannis, Athina Boulaka, Aggeliki K Meligova, George Lambrinidis, Eleftherios Kalpoutzakis, Harris Pratsinis, Antigoni Cheilari, Dimitra J Mitsiou, Sofia Mitakou, Michael N Alexis   +11 more
doaj   +1 more source

Genistein inhibits radiation-induced activation of NF-κB in prostate cancer cells promoting apoptosis and G₂/M cell cycle arrest

BMC Cancer, 2006
Background New cancer therapeutic strategies must be investigated that enhance prostate cancer treatment while minimizing associated toxicities. We have previously shown that genistein, the major isoflavone found in soy, enhanced prostate cancer ...
Forman Jeffrey D, Kucuk Omer, Wang Yu, Raffoul Julian J, Sarkar Fazlul H, Hillman Gilda G   +5 more
doaj   +1 more source

A highly selective cell-based fluorescent biosensor for genistein detection

Engineering Microbiology, 2023
Genistein, an isoflavone found mainly in legumes, has been shown to have numerous health benefits for humans. Therefore, there is substantial interest in producing it using microbial cell factories.
Lucy Fang-I Chao, Dany Liu, Verena Siewers   +2 more
doaj   +1 more source

Genistein and Curcumin Inhibit Proliferation and Invasiveness in BRAFV600E Mutant and Wild-Type Melanoma Cells: Insights into Their Anticancer Effects

Biomedicines
Background/objectives: Melanoma is one of the deadliest forms of malignant cancers; ultraviolet radiation exposure together with genetic mutations, such as BRAF, represent the main risk factors and are involved in metastatic dissemination.
Federico Vaccaro, Federica Mannino, Mariacarmela Santarpia, Chiara Cullotta, Mariarosaria Galeano, Francesco Borgia, Federica Li Pomi, Vincenzo Arcoraci, Maria Lentini, Mariausilia Franchina, Mario Vaccaro, Giovanni Pallio, Natasha Irrera   +12 more
doaj   +1 more source

Genistein alleviates colitis by suppressing inflammation and modulating colonic Marvinbryantia formatexigens abundance and metabolites

Current Research in Food Science
As an active ingredient of leguminous plants, genistein is extremely important for alleviating various human diseases. However, the regulatory effect of genistein on intestinal microbiota in alleviating enteritis is still unclear.
Yang He, Xiaoli Qin, Chaoyong Liao, Rafaela Lameira Souza Lima, Qihang Hou, Jiaqi Lei, Yujiao Lai, Qiuyu Jiang, Bo Wang, Bingkun Zhang   +9 more
doaj   +1 more source

Genistein Inhibits Human Colorectal Cancer Growth and Suppresses MiR-95, Akt and SGK1

Cellular Physiology and Biochemistry, 2015
Background: Genistein, a major isoflavonoid isolated from dietary soybean, has been shown to suppress the growth of several cancers through modulation of various pathways.
Jian Qin, Jia Xin Chen, Zhou Zhu, Jia An Teng   +3 more
doaj   +1 more source

Genistein: A Potent Natural Antiandrogen [PDF]

Clinical Chemistry, 2000
Flavonoids and other polyphenolic natural compounds have attracted much attention as candidate cancer preventive and anticarcinogenic agents, as well as antiatherogenic and antioxidant compounds (1). Although the public now consumes these compounds in substantial amounts from dietary sources, food supplements, and more recently, as “nutraceutical ...
R S, Rosenberg Zand, D J, Jenkins, E P, Diamandis   +2 more
openaire   +2 more sources

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source