Results 31 to 40 of about 37,169 (239)

Biological evaluation of isoflavonoids from Genista halacsyi using estrogen-target cells: Activities of glucosides compared to aglycones.

PLoS ONE, 2019
The purpose of this study was to evaluate the response of estrogen target cells to a series of isoflavone glucosides and aglycones from Genista halacsyi Heldr.
Nikolas Fokialakis, Xanthippi Alexi, Nektarios Aligiannis, Athina Boulaka, Aggeliki K Meligova, George Lambrinidis, Eleftherios Kalpoutzakis, Harris Pratsinis, Antigoni Cheilari, Dimitra J Mitsiou, Sofia Mitakou, Michael N Alexis   +11 more
doaj   +1 more source

Genistein inhibits radiation-induced activation of NF-κB in prostate cancer cells promoting apoptosis and G₂/M cell cycle arrest

BMC Cancer, 2006
Background New cancer therapeutic strategies must be investigated that enhance prostate cancer treatment while minimizing associated toxicities. We have previously shown that genistein, the major isoflavone found in soy, enhanced prostate cancer ...
Forman Jeffrey D, Kucuk Omer, Wang Yu, Raffoul Julian J, Sarkar Fazlul H, Hillman Gilda G   +5 more
doaj   +1 more source

A highly selective cell-based fluorescent biosensor for genistein detection

Engineering Microbiology, 2023
Genistein, an isoflavone found mainly in legumes, has been shown to have numerous health benefits for humans. Therefore, there is substantial interest in producing it using microbial cell factories.
Lucy Fang-I Chao, Dany Liu, Verena Siewers   +2 more
doaj   +1 more source

Genistein Inhibits Human Colorectal Cancer Growth and Suppresses MiR-95, Akt and SGK1

Cellular Physiology and Biochemistry, 2015
Background: Genistein, a major isoflavonoid isolated from dietary soybean, has been shown to suppress the growth of several cancers through modulation of various pathways.
Jian Qin, Jia Xin Chen, Zhou Zhu, Jia An Teng   +3 more
doaj   +1 more source

Genistein alleviates colitis by suppressing inflammation and modulating colonic Marvinbryantia formatexigens abundance and metabolites

Current Research in Food Science
As an active ingredient of leguminous plants, genistein is extremely important for alleviating various human diseases. However, the regulatory effect of genistein on intestinal microbiota in alleviating enteritis is still unclear.
Yang He, Xiaoli Qin, Chaoyong Liao, Rafaela Lameira Souza Lima, Qihang Hou, Jiaqi Lei, Yujiao Lai, Qiuyu Jiang, Bo Wang, Bingkun Zhang   +9 more
doaj   +1 more source

Genistein induces oestrogen receptor-alpha gene expression in osteoblasts through the activation of mitogen- activated protein kinases/NF-kappa B/activator protein-1 and promotes cell mineralisation

, 2017
Oestrogen and oestrogen receptors (ER) play critical roles in the maintenance of bone remodelling. Genistein, structurally similar to 17-oestradiol, is a phyto-oestrogen that may be beneficial for treating osteoporosis. In the present study, we evaluated
劉興華, Liao, Mei-Hsiu;Tai, Yu-Ting;Cherng, Yih-Giun;Liu, Shing-Hwa;Chang, Ya-An;Lin, Pei-I;Chen, Ruei-Ming   +1 more
core   +1 more source

Genistein and Curcumin Inhibit Proliferation and Invasiveness in BRAFV600E Mutant and Wild-Type Melanoma Cells: Insights into Their Anticancer Effects

Biomedicines
Background/objectives: Melanoma is one of the deadliest forms of malignant cancers; ultraviolet radiation exposure together with genetic mutations, such as BRAF, represent the main risk factors and are involved in metastatic dissemination.
Federico Vaccaro, Federica Mannino, Mariacarmela Santarpia, Chiara Cullotta, Mariarosaria Galeano, Francesco Borgia, Federica Li Pomi, Vincenzo Arcoraci, Maria Lentini, Mariausilia Franchina, Mario Vaccaro, Giovanni Pallio, Natasha Irrera   +12 more
doaj   +1 more source

Unveiling the Diagnostic Value and Potential Therapeutic Targets of Phenylalanine Metabolism in Pancreatic Cancer via Integrated Multi‐Omics and Machine Learning [PDF]

FASEB J
MR identified phenylalanine as a causal PC risk factor (OR 1.18). A 5‐gene RF model (AUC 0.955) highlighted SLC6A14 as the top biomarker. Single‐cell analysis revealed epithelial–immune crosstalk. Molecular docking identified genistein (−9.1 kcal/mol) as a lead SLC6A14‐targeting compound.
Liu X, Li Y, Qin F, Ou J.
europepmc   +2 more sources

An Artificially Selected Cytokinin‐Pathway Transcription Factor Balances Soybean Yield and Pathogen Resistance

Advanced Science, EarlyView.
A cytokinin pathway transcription factor, RR2b, was artificially selected during soybean domestication and improvement based on its differential transcriptional activity, which correlates with ATT repeat polymorphisms in its promoter. RR2b balances yield and defense by fine‐tuning its expression level and offers a promising target for decoupling trade ...
Qun Ma, Yaqing Chen, Yiwen Gao, Xueting Hu, Qun Yang, Yucheng Liu, Peiyong Xin, Jijun Yan, Jinfang Chu, Lei Li, Zhixi Tian, Bo Ren   +11 more
wiley   +1 more source

The effect of various acidic solutions on the concentration of genistein in tempeh [PDF]

, 2000
Plan BTempeh is a fermented soyfood that contains a higher level of genistein in comparison to nonfermented soyfoods, such as tofu and soymilk. Control tempehs prepared in this research contained concentrations of genistein seven times greater (49.70 ...
Garlock, Lori A.
core