Genistein upregulates LDLR levels via JNK-mediated activation of SREBP-2
Food & Nutrition Research, 2016 Background: Genistein has been proved in vitro and in vivo to lower LDLR level. It is also widely consumed and implicated for its anti-atherogenic effects.
Medicia Kartawijaya +3 more
doaj +1 more source
Genistein improves spatial learning and memory in male rats with elevated glucose level during memory consolidation [PDF]
, 2015 Cognitive dysfunction due to higher blood glucose level has been reported previously. Genistein (GEN) is a phytoestrogen that we hypothesized might lead to improved memory, despite elevated blood glucose levels at the time of memory consolidation.
Kuwahara, Rika +5 more
core +1 more source
Antioxidants, 2019 We examined the anti-cancer effect of genistein, a soy-derived isoflavone, in human bladder transitional cell carcinoma T24 cells. According to our data, genistein induced G2/M phase arrest of the cell cycle and apoptosis.
Cheol Park +12 more
doaj +1 more source
Genistein Exposure Interferes with Pharmacokinetics of Celecoxib in SD Male Rats by UPLC-MS/MS
Biochemistry Research International, 2017 Objective. To discuss the effects of genistein on the metabolism of celecoxib in vitro and in vivo. Method. In vitro, the effects of genistein on the metabolism of celecoxib were studied using rat and human liver microsomes.
Xiang Zheng +5 more
doaj +1 more source
Formation of phosphoglycosides in Caenorhabditis elegans: a novel biotransformation pathway. [PDF]
PLoS ONE, 2012 BACKGROUND: Caenorhabditis elegans (C. elegans) has become a widely used model to explore the effect of food constituents on health as well as on life-span extension.
Sebastian T Soukup +5 more
doaj +1 more source
Daidzein and genistein content of cereals [PDF]
European Journal of Clinical Nutrition, 2002 To analyse 75 cereals and three soy flours commonly eaten in Europe for the phytoestrogens daidzein and genistein.The phytoestrogens daidzein and genistein were extracted from dried foods, and the two isoflavones quantified after hydrolytic removal of any conjugated carbohydrate.
J, Liggins +3 more
openaire +2 more sources
Genistein-Derived ROS-Responsive Nanoparticles Relieve Colitis by Regulating Mucosal Homeostasis
, 2021 Disruption of intestinal homeostasis is an important event in the development of inflammatory bowel disease (IBD), and genistein (GEN) is a candidate medicine to prevent IBD.
Shuo Zhang +23 more
core +1 more source
Genistein prevents bone loss in type 2 diabetic rats induced by streptozotocin
Food & Nutrition Research, 2020 Background: Diabetic osteoporosis has become a severe public health problem in the aging societies. Genistein has been reported to play an important role in preventing and treating metabolic diseases via its anti-inflammatory, antioxidant, anti ...
Rongrong Lu +3 more
doaj +1 more source
Potential effects of phytoestrogen genistein in modulating acute methotrexate chemotherapy-induced osteoclastogenesis and bone damage in rats [PDF]
, 2015 Chemotherapy-induced bone damage is a frequent side effect which causes diminished bone mineral density and fracture in childhood cancer sufferers and survivors.
Tristan King +20 more
core +1 more source
Activation of Chloride Secretion by Isoflavone Genistein in Endometrial Epithelial Cells
Cellular Physiology and Biochemistry, 2013 Background /Aim: Genistein, the most active isoflavone found primarily in soybeans, alters ion transport functions in intestinal and airway epithelia.
Chatsri Deachapunya +1 more
doaj +1 more source