Results 41 to 50 of about 37,169 (239)

Effects of Genistein on Common Kidney Diseases

, 2022
Genistein is a naturally occurring phytoestrogen (soy or soybean products) that is classified as an isoflavone, and its structure is similar to that of endogenous estrogens; therefore, genistein can exert an estrogen-like effect via estrogen receptors ...
Chaoran Chen, Li, Yuanyuan, Chen, Chaoran, Xie, Zhenxing, Zhang, Yiming, Peng, Qianwen, Qianwen Peng, Yuanyuan Li, Liang, Yipei, Haitao Huang, Shang, Jia, Yipei Liang, Yueming Ding, Ding, Yueming, Yiming Zhang, Jia Shang, Huang, Haitao, Zhenxing Xie   +17 more
core   +1 more source

Nanovesicles With Mechanically Induced Adjuvanticity for Robust Melanoma Vaccination Toward Tumor‐Associated Macrophages

Advanced Science, EarlyView.
Rigidity‐tunable nanovesicle (P‐Pm) with mechanically induced adjuvanticity toward tumor‐associated macrophages (TAMs) was designed to engineer R848/gp100 antigen ‐loaded nanovaccine (P@Rg‐Pm), which achieved outstanding anti‐tumor outcomes in both therapeutic and preventive model of B16‐F10 melanoma.
Bangyue Luo, Liyan Qiu
wiley   +1 more source

Cell Cycle Modulation of CHO-K1 Cells Under Genistein Treatment Correlates with Cells Senescence, Apoptosis and ROS Level but in a Dose-Dependent Manner [PDF]

Advanced Pharmaceutical Bulletin, 2019
Purpose: Genistein, a soy isoflavone, exhibits a biphasic effect on cells proliferation with some different effects between ER-alpha and ER-beta. The objective of this present study is to determine the modulatory effect based on cell cycle progression ...
Riris Istighfari Jenie, Nur Dina Amalina, Gagas Pradani Nur Ilmawati, Rohmad Yudi Utomo, Muthi Ikawati, Annisa Khumaira, Jun- Ya Kato, Edy Meiyanto   +7 more
doaj   +1 more source

Self‐Amplified Activatable Fluorescent Probe for Early Diagnosis of Acute Kidney Injury and High‐Throughput Screening of Natural Protectants

Advanced Science, EarlyView.
The PS‐QRC nanoprobe employs L‐serine as a targeting ligand for kidney injury molecule‐1 (KIM‐1) to achieve accumulation in injured renal tissues. Upon activation by reactive oxygen species (ROS), it undergoes a self‐amplifying cascade to release fluorophores for near‐infrared fluorescence (NIRF) imaging, enabling ultra‐early diagnosis of acute kidney ...
Yahui Chen, Meihong Liu, Mengchao Ding, Ye Liu, Chuanxu Zhu, Mingye Gong, Zhixuan Huang, Yi Zhang, Wei Xue, Youyong Yuan, Kewei Wang   +10 more
wiley   +1 more source

The effect of dietary genistein on breast cancer metastasis [PDF]

, 2010
The dietary isoflavone supplements are now perceived as safe and a natural alternative to hormone replacement therapy (HRT) and are recently being consumed by postmenopausal women.
Fung, Chung Yan
core  

Genistein modulates MMP-26 and estrogen receptor expression in endometrial cancer cells

Journal of Traditional Chinese Medical Sciences, 2016
Objective: To explore the mechanism of the estrogen-like effect of genistein by observing the expression of Matrix metalloproteinases-26 (MMP-26) and ERα in human endometrial cancer cells (Ishikawa and HEC-1B) in vitro.
Xiaoli Liu, Xiaoou Xue, Hao Wang, Xiaomei Xu   +3 more
doaj   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

Effects of dose and route of administration of genistein on isoflavone concentrations in post-weaned and gestating sows

Animal, 2013
Phytoestrogens could be a useful tool in swine husbandry practices because of their structural and functional similarities to estradiol. The goal of this study was to compare various routes and doses of administration of the phytoestrogen genistein in ...
C. Farmer, P. Robertson, G.S. Gilani
doaj   +1 more source

Estrogen receptor targeting with genistein radiolabeled Technetium-99m as radiotracer of breast cancer: Its optimization, characterization, and predicting stability constants by DFT calculation

Heliyon, 2023
Objective: Genistein is an isoflavone molecule with a high affinity for estrogen receptors (ER), which could lead to the mechanism of selective estrogen receptor modulators (SERMs) in breast cancer.
Danni Ramdhani, Nita Listiani, Maula Eka Sriyani, Eva Maria W, Hiroshi Watabe, Resmi Mustarichie, Sri Agung Fitri Kusuma, Regaputra S. Janitra   +7 more
doaj   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source