Results 111 to 120 of about 786,469 (327)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Ecological and economic implications of alternative metrics in biodiversity offset markets. [PDF]

Conserv Biol, 2022
Simpson KH, de Vries FP, Dallimer M, Armsworth PR, Hanley N.   +4 more
europepmc   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

The Simplest Evaluation Measures for XML Information Retrieval that Could Possibly Work [PDF]

, 2005
This paper reviews several evaluation measures developed for evaluating XML information retrieval (IR) systems. We argue that these measures, some of which are currently in use by the INitiative for the Evaluation of XML Retrieval (INEX), are complicated,
Hiemstra, D., Mihajlovic, V.
core   +3 more sources

Referee report. For: What gives a stroke publication impact? Assessing traditional and alternative metrics of scientific impact for papers published in the journal Stroke [version 1; peer review: 1 approved with reservations, 1 not approved]

, 2021
Robin Haunschild
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Existence of Generalized Maxwell–Einstein Metrics on Completions of Certain Line Bundles

Mathematics
In Kähler geometry, Calabi extremal metrics serves as a class of more available special metrics than Kähler metrics with constant scalar curvatures, as a generalization of Kähler Einstein metrics. In recent years, Maxwell–Einstein metrics (or conformally
Jing Chen, Daniel Guan
doaj   +1 more source

An Update on Measures of Preoperative Glycemic Control

Plastic and Reconstructive Surgery, Global Open, 2019
Summary:. Glycemic control represents a modifiable preoperative risk factor in surgery. Traditionally, hemoglobin A1c (HbA1c) and plasma glucose are utilized as measures of glycemic control.
Ledibabari M. Ngaage, MA, MB Bchir, Emmanuel N. Osadebey, MD, Sebastian T.E. Tullie, BA, MB BChir, Adekunle Elegbede, MD, PhD, Erin M. Rada, MD, Elias K. Spanakis, MD, Nelson Goldberg, MD, Sheri Slezak, MD, Yvonne M. Rasko, MD   +8 more
doaj   +1 more source

Alternative metrics for characterizing longer-term clinical outcomes in difficult-to-treat depression: I. Association with change in quality of life. [PDF]

Psychol Med, 2023
Sackeim HA, Rush AJ, Greco T, Jiang M, Badejo S, Bunker MT, Aaronson ST, Aaronson ST, Conway CR, Demyttenaere K, Young AH, Young AH, McAllister-Williams RH.   +12 more
europepmc   +1 more source

Inequality Comparisons in a Multi-Period Framework: The Role of Alternative Welfare Metrics [PDF]

This paper considers the use of alternative welfare metrics in evaluations of income inequality in a multi-period context. Using Norwegian longitudinal income data, it is found, as in many studies, that inequality is lower when each individual’s annual ...
Elin Halvorsen, John Creedy, Thor O. Thoresen   +2 more
core