Results 131 to 140 of about 4,659,127 (281)

The Simplest Evaluation Measures for XML Information Retrieval that Could Possibly Work [PDF]

, 2005
This paper reviews several evaluation measures developed for evaluating XML information retrieval (IR) systems. We argue that these measures, some of which are currently in use by the INitiative for the Evaluation of XML Retrieval (INEX), are complicated,
Hiemstra, D., Mihajlovic, V.
core   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A comparison of metrics for estimating phylogenetic signal under alternative evolutionary models

Genetics and Molecular Biology, 2012
Several metrics have been developed for estimating phylogenetic signal in comparative data. These may be important both in guiding future studies on correlated evolution and for inferring broad-scale evolutionary and ecological processes (e.g ...
José Alexandre F. Diniz-Filho, Thiago Santos, Thiago Fernando Rangel, Luis Mauricio Bini   +3 more
doaj  

Relationship Between Effective Dose, Alternative Metrics, and SSDE: Experiences with Two CT Dose-Monitoring Systems

Diagnostics
Background: We assessed the frequency and causes of discrepancies in CT dose indices such as dose-length product (DLP), size-specific dose estimate (SSDE), and effective dose (ED), as calculated by CT dose-monitoring systems.
Lilla Szatmáriné Egeresi, László Urbán, Zsolt Dankó, Ervin Balázs, Ervin Berényi, Mária Marosi, János Kiss, Péter Bágyi, Zita Képes, Miklós Emri, László Balkay   +10 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Bibliometric analysis of alternative performance metrics for peri‐operative, critical care and pain medicine journals [PDF]

, 2021
Argyro Fassoulaki, Athanasia Τsaroucha, Georgia Micha, Eleftheria Soulioti   +3 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

A neural net-based approach to software metrics [PDF]

Software metrics provide an effective method for characterizing software. Metrics have traditionally been composed through the definition of an equation.
Boetticher, G., Eichmann, David A., Srinivas, Kankanahalli   +2 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source