Results 131 to 140 of about 786,469 (327)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Analysis of classification metric behaviour under class imbalance

open access: yesEgyptian Informatics Journal
Class imbalance is the phenomenon defined as skewed target variable distributions in a dataset. In other words class imbalance occurs when a dataset has an unequal proportion of target variables assigned to the instances in the dataset.
Jean-Pierre van Zyl   +1 more
doaj   +1 more source

Of models and metrics: the UK debate on assessing humanities research [PDF]

open access: yes, 2006
Professor Michael Worton (UCL) is the Chair of an expert group set up in July 2006 by the Arts & Humanities Research Council to examine alternative ways to assess research.
Worton, M.
core  

Two-dimensional Riemannian and Lorentzian geometries from second order ODEs

open access: yes, 2004
In this note we give an alternative geometrical derivation of the results recently presented by Garcia-Godinez, Newman and Silva-Ortigoza in [1] on the class of all two-dimensional riemannian and lorentzian metrics from 2nd order ODEs which are in ...
Emanuel Gallo, Nurowski P.
core   +4 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Restoration of star-field images using high-level languages and core libraries [PDF]

open access: yes, 2007
Research into the use of FPGAs in Image Processing began in earnest at the beginning of the 1990s. Since then, many thousands of publications have pointed to the computational capabilities of FPGAs. During this time, FPGAs have seen the application space
Bruce, R.   +3 more
core  

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Metric-Driven Voronoi Diagrams: A Comprehensive Mathematical Framework

open access: yesComputation
Voronoi partitioning is a fundamental geometric concept with applications across computational geometry, robotics, optimization, and resource allocation.
Vishnu G. Nair
doaj   +1 more source

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