Results 101 to 110 of about 3,987,830 (319)

The Novel J-Domain Protein Mrj1 Is Required for Mitochondrial Respiration and Virulence in Cryptococcus neoformans

mBio, 2020
The opportunistic fungal pathogen Cryptococcus neoformans must adapt to the mammalian environment to establish an infection. Proteins facilitating adaptation to novel environments, such as chaperones, may be required for virulence.
Linda C. Horianopoulos, Guanggan Hu, Mélissa Caza, Kerstin Schmitt, Peter Overby, James D. Johnson, Oliver Valerius, Gerhard H. Braus, James W. Kronstad   +8 more
doaj   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Fungal respiration: a fusion of standard and alternative components [PDF]

, 2001
In animals, electron transfer from NADH to molecular oxygen proceeds via large respiratory complexes in a linear respiratory chain. In contrast, most fungi utilise branched respiratory chains.
Holloman, D. W., Tim Joseph-Horne, Wood, Paul M., Joseph-Horne, Tim, Derek W. Hollomon, Joseph-Horne, T., Hollomon, Derek W., Wood, P. M., Paul M. Wood   +8 more
core   +1 more source

An In Silico Model Of The Alternative Oxidase

, 2009
ABSTRACT The alternative oxidase (AOX) is a member of the family of di-iron proteins, in which the catalytic centre consists of a pair of iron atoms ligated by carboxylate (aspartate and glutamate) and histidine ligands within a four helix bundle.
Pang, Shu-Ying Marissa, Tristram, Stephen, Brown, Simon   +2 more
openaire   +2 more sources

Blood Biomarkers and Surface‐Enhanced Raman Spectroscopy for Gout: A Comprehensive Review

Advanced Functional Materials, EarlyView.
Schematic illustrating gout disease progression from asymptomatic hyperuricemia to chronic tophaceous disease, highlighting the limitations of conventional imaging and biochemical diagnostics and the potential of engineered SERS platforms for ultrasensitive blood‐based detection of urate‐related biomarkers across disease stages, with the color gradient
Isuri Perera, Chiranjeevi Kanike, Appurva Tiwari, Hongyan Wu, Larry D. Unsworth, Ben Bin Xu, Xuehua Zhang   +6 more
wiley   +1 more source

Prokaryotic origins for the mitochondrial alternative oxidase and plastid terminal oxidase nuclear genes

, 2003
The mitochondrial alternative oxidase is a diiron carboxylate quinol oxidase (Dox) found in plants and some fungi and protists, but not animals. The plastid terminal oxidase is distantly related to alternative oxidase and is most likely also a Dox ...
Patrick M Finnegan, Jackie A Wilce, Umbach, Ann L, Finnegan, Patrick M, Ann L Umbach, Wilce, Jackie A   +5 more
core   +1 more source

Alternative Oxidase Transcription Factors AOD2 and AOD5 of Neurospora crassa Control the Expression of Genes Involved in Energy Production and Metabolism

G3: Genes, Genomes, Genetics, 2017
In Neurospora crassa, blocking the function of the standard mitochondrial electron transport chain results in the induction of an alternative oxidase (AOX). AOX transfers electrons directly from ubiquinol to molecular oxygen.
Zhigang Qi, Kristina M. Smith, Erin L. Bredeweg, Natasa Bosnjak, Michael Freitag, Frank E. Nargang   +5 more
doaj   +1 more source

The mitochondrial alternative oxidase Aox1 is needed to cope with respiratory stress but dispensable for pathogenic development in Ustilago maydis

PLoS ONE, 2017
The mitochondrial alternative oxidase is an important enzyme that allows respiratory activity and the functioning of the Krebs cycle upon disturbance of the respiration chain.
C. Cárdenas-Monroy, T. Pohlmann, G. Piñón-Zárate, Genaro Matus-Ortega, G. Guerra, M. Feldbrügge, J. P. Pardo   +6 more
semanticscholar   +1 more source

Bacterial‐Electrochemical Platform Utilizing a MXene‐Peptide Hydrogel

Advanced Functional Materials, EarlyView.
A peptide‐based fibrillar hydrogel incorporating MXene facilitates efficient electron delivery to intracellular recombinant [FeFe]‐hydrogenase enzyme in E. coli, enabling sustained bioelectrochemical H2 production without engineered exoelectrogenicity pathways.
Oren Ben‐Zvi, Itzhak Grinberg, Or Messer, Dana Cohen‐Gerassi, Maxim Sokol, Iftach Yacoby, Lihi Adler‐Abramovich   +6 more
wiley   +1 more source

New sequence data enable modelling of the fungal alternative oxidase and explain an absence of regulation by pyruvate

, 2000
Respiratory rates involving the alternative oxidase (AO) were studied in mitochondria from Tapesia acuformis. There was no evidence for regulation by pyruvate, in contrast with plant AO.
Hollomon, D. W., Tim Joseph-Horne, Richard B Sessions, Derek Hollomon, Babij, J., Joanna Babij, Hollomon, Derek, Paul M Wood, Joseph-Horne, Tim, Sessions, R. B., Babij, Joanna, Joseph-Horne, T., Sessions, Richard B, Wood, Paul M, Wood, P. M.   +14 more
core   +1 more source