Results 101 to 110 of about 3,146,246 (278)

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Habitat selection when killing primary versus alternative prey species supports prey specialization in an apex predator

open access: yes, 2019
© 2019 The Zoological Society of London Many predators specialize on one or several prey species that they select from the range of potential prey. Predator specialization on primary versus alternative prey is driven in part by encounter rates with prey ...
ML Allen (8963465)   +14 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Experimental evidence quantifying effects of nocturnal light conditions on predation levels by riverine predators on larval prey

open access: yesJournal of Freshwater Ecology
Larval fish and aquatic macroinvertebrates are believed to be at greater predation risk by visual riverine predators during periods of higher lunar illumination.
Joseph J. Riedy   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Impact of alternative prey on predator strategy and -state when defended prey are non-mimetic.

open access: yes, 2017
Effect of availability of alternative prey (fγ) on predator strategy (a, c, e) and stationary distribution of predator state (b, d, f) in the non-mimetic treatment. Results are shown for three values of availability of alternative prey (a, b) γ = 0.1, (c,
John Skelhorn (308287)   +4 more
core   +1 more source

Identifying realistic recovery targets and conservation actions for tigers in a human dominated landscape using spatially-explicit densities of wild prey and their determinants [PDF]

open access: yes, 2014
Aim Setting realistic population targets and identifying actions for site and landscape-level recovery plans are critical for achieving the global target of doubling wild tiger numbers by 2022.
MacMillan, Douglas C.   +2 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Home - About - Disclaimer - Privacy