Translophagy—A potential link between autophagy impairment and translational errors
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Appendix G. Prey excursion size in relation to alternative metric of chronic predation risk.
Prey excursion size in relation to alternative metric of chronic predation ...
Elizabeth M. P. Madin (180610) +2 more
core +1 more source
Meta-analysis of the effects of predation on animal prey abundance: evidence from UK vertebrates [PDF]
Background: Controlling vertebrate predators is one of the most widespread forms of wildlife management and it continues to cause conflict between stakeholders worldwide. It is important for managers and policy-makers to make decisions on this issue that
Alison R Holt +15 more
core +1 more source
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Appendix H. Prey excursion size in relation to alternative metric of acute predation risk.
Prey excursion size in relation to alternative metric of acute predation ...
Elizabeth M. P. Madin (180610) +2 more
core +1 more source
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Interactions between Plutella xylostella, Diadegma semiclausum and some generalist predators of brassica crops. [PDF]
While much is known about the diamondback moth, Plutella xylostella (L.) (Plutellidae) (DBM), the most important pest of brassica crops worldwide, there is little understanding about the dynamics of predatory invertebrates in brassica systems.
Lankin Vega, Gabriela
core
“Leave-one-prey-out” analysis.
“Leave-one-prey-out” analysis.
Kathlin Schweitzer (7288469) +2 more
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source

