Results 71 to 80 of about 2,311,382 (303)

Muscleblind proteins regulate alternative splicing [PDF]

The EMBO Journal, 2004
Although the muscleblind (MBNL) protein family has been implicated in myotonic dystrophy (DM), a specific function for these proteins has not been reported. A key feature of the RNA-mediated pathogenesis model for DM is the disrupted splicing of specific pre-mRNA targets.
Thai H, Ho, Nicolas, Charlet-B, Michael G, Poulos, Gopal, Singh, Maurice S, Swanson, Thomas A, Cooper   +5 more
openaire   +2 more sources

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

A Systematic Literature Review of Cultured Meat Through the Conceptual Frameworks of the Entrepreneurial Ecosystem and Global Value Chain

Foods
Cultured meat (CM) is currently experiencing a surge in popularity, primarily due to its promise to produce animal-based products with a lower environmental impact and a higher level of animal welfare. Although CM production remains limited and lacks pre-
Chiara Benussi, Antonella Samoggia
doaj   +1 more source

The dynamical transition in proteins and non-Gaussian behavior of low frequency modes in Self Consistent Normal Mode Analysis [PDF]

, 2010
Self Consistent Normal Mode Analysis (SCNMA) is applied to heme c type cytochrome f to study temperature dependent protein motion. Classical Normal Mode Analysis (NMA) assumes harmonic behavior and the protein Mean Square Displacement (MSD) has a linear ...
B. Melchers, E. Prohofsky, Earl Prohofsky, Earl W. Prohofsky, H. Nakagawa, Jianguang Guo, Joshua M. Ward, Timo Budarz, W. Doster   +8 more
core   +3 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Novel Endo-β-N-Acetylglucosaminidases Derived from Human Fecal Samples Selectively Release N-Glycans from Model Glycoproteins

Foods
Three novel endo-β-N-acetylglucosaminidases (AVUL01, BCAC01, and BFIN01) classified as members of the glucoside hydrolase (GH) family 18 were identified from human fecal samples and then cloned and characterized for their ability to hydrolyze two ...
Matthew Bolino, Nadini Haththotuwe Gamage, Hatice Duman, Odunayo Abiodun, Amilton S. De Mello, Sercan Karav, Steven A. Frese   +6 more
doaj   +1 more source

mEAK-7 Forms an Alternative mTOR Complex with DNA-PKcs in Human Cancer. [PDF]

, 2019
MTOR associated protein, eak-7 homolog (mEAK-7), activates mechanistic target of rapamycin (mTOR) signaling in human cells through an alternative mTOR complex to regulate S6K2 and 4E-BP1.
Fox, Alexandra Lucienne, Haidar, Fatima Sarah, Kim, Jin Koo, Krebsbach, Paul H, Mendonça, Daniela Baccelli, Nguyen, Joe Truong, Ray, Connor   +6 more
core  

Development of an alternative approach to protein crystallization [PDF]

Journal of Structural and Functional Genomics, 2007
We are developing an alternate strategy for the crystallization of macromolecules that does not, like current methods, depend on the optimization of traditional variables such as pH and precipitant concentration, but is based on the hypothesis that many conventional small molecules might establish stabilizing, intermolecular, non covalent crosslinks in
McPherson, Alexander, Nguyen, Chieniang, Larson, Steven B, Day, John S, Cudney, Bob   +4 more
openaire   +4 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Consumption of a high-fat meal containing cheese compared with a vegan alternative lowers postprandial C-reactive protein in overweight and obese individuals with metabolic abnormalities: a randomised controlled cross-over study. [PDF]

, 2016
Dietary recommendations suggest decreased consumption of SFA to minimise CVD risk; however, not all foods rich in SFA are equivalent. To evaluate the effects of SFA in a dairy food matrix, as Cheddar cheese, v.
Demmer, Elieke, German, J Bruce, Gertz, Erik R, Rivera, Nancy, Rogers, Tara S, Smilowitz, Jennifer T, Van Loan, Marta D, Zivkovic, Angela M   +7 more
core   +1 more source