Results 71 to 80 of about 1,434,923 (313)

Initial mutations direct alternative pathways of protein evolution

, 2011
Whether evolution is erratic due to random historical details, or is repeatedly directed along similar paths by certain constraints, remains unclear. Epistasis (i.e.
J Arjan G M de Visser, Tawfik Dan S., Salverda, M.L.M., Merijn L M Salverda, Hoekstra, R.F., Salverda Merijn L. M., Dellus, E., John van der Oost, Alfons J M Debets, Visser, J.A.G.M., de, Gorter Florien A., de Visser J. Arjan G. M., Florien A Gorter, Dellus Eynat, Dan S Tawfik, Gorter, F.A., Debets Alfons J. M., van der Oost John, Eynat Dellus, Hoekstra Rolf F., Debets, A.J.M., Oost, J., van der, J. Arjan G. M. de Visser, Merijn L. M. Salverda, Tawfik, D.S., Florien A. Gorter, Alfons J. M. Debets, Rolf F Hoekstra, de Visser, J.A.G.M., van der Oost, J., Rolf F. Hoekstra, Dan S. Tawfik   +31 more
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Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes [PDF]

, 2014
Aims/hypothesis: Impaired glucose uptake in skeletal muscle is an important contributor to glucose intolerance in type 2 diabetes. The aspartate protease, beta-site APP-cleaving enzyme 1 (BACE1), a critical regulator of amyloid precursor protein (APP ...
Hamilton, D. Lee, Montagut , Gemma, Meakin, Paul J., Susan M. Jalicy, Meakin, PJ, D. Lee Hamilton, Dawn Bestow, Bestow, D, Hamilton, DL, Montagut, G, Michael L. J. Ashford, Jalicy, Susan M., Findlay, John A., Jalicy, SM, Ashford, MLJ, Ashford, Michael L. J.; id_orcid, Montagut, Gemma, John A. Findlay, Gemma Montagut, Meakin, Paul J, Ashford, Michael L J, Bestow, Dawn, Findlay, John A, Jalicy, Susan M, Hamilton, David Lee, Findlay, JA, Paul J. Meakin   +26 more
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The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Large-scale analysis of human alternative protein isoforms: pattern classification and correlation with subcellular localization signals

, 2005
We investigated human alternative protein isoforms of >2600 genes based on full-length cDNA clones and SwissProt. We classified the isoforms and examined their co-occurrence for each gene.
Nakao, M., Suwa, M., Motono, C., Barrero, R.A., Mukai, Y., Nakai, K.   +5 more
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Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

SIRT1 Undergoes Alternative Splicing in a Novel Auto-Regulatory Loop with p53

, 2010
Background The NAD-dependent deacetylase SIRT1 is a nutrient-sensitive coordinator of stress-tolerance, multiple homeostatic processes and healthspan, while p53 is a stress-responsive transcription factor and our paramount tumour suppressor. Thus, SIRT1-
Ahmed, Shafiq U., Milner, J, Jack Ford, Li, Han, Li, H, Ford, J, Serrano, M, Lynch, CJ, Milner, Jo, Ford Jack, Han Li, Blagosklonny, Mikhail V., Ahmed, Shafiq, Allison, SJ, Jo Milner, Simon J Allison, Simon J. Allison, Manuel Serrano, Warnock Lorna J., Warnock, LJ, Lorna J Warnock, Zahid H. Shah, Shafiq U Ahmed, Lorna J. Warnock, Serrano, Manuel, Shah, ZH, Lynch Cian J., Shah, Zahid H., Allison, Simon J., Shah Zahid H., Shafiq U. Ahmed, Serrano Manuel, Milner Jo, Cian J. Lynch, Lynch, Cian J., Li Han, Ahmed Shafiq U., Allison Simon J., Ford, Jack, Warnock, Lorna J., Cian J Lynch, Zahid H Shah   +41 more
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Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Consumer alternative protein choice in climate change: temporal landmarks, self-transcendence, and mindset abstraction

This study explores consumer preferences for alternative proteins within the context of pro-environmental choices. The primary objective is to identify and analyze the factors influencing consumers' choices between alternative and traditional proteins ...
Zhang, Yunen, Bu, Yi, Nguyen, Mai
core   +1 more source

Protein based plastics from the residuals of industrial oil crops [PDF]

, 2012
The factors that can be utilized in the development of new protein based plastic materials from industrial oilseeds are examined. As this area has not been explored in depth in the literature, experiences from the study of other proteins are used to ...
Newson, William R.
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